Objectively measured sleep duration and plasma glucose values following an oral glucose tolerance test amongst pregnant women with obesity in the UK

Redfern, Kathy M.; Hine, Rachel S.; Hollands, Heidi; Welch, C.; Pinkney, Jonathan; Rees, Gail

doi:10.1016/j.sleep.2019.01.017

Cited by 9 publications

(5 citation statements)

References 18 publications

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“…Published studies show that self-reported and objectively assessed sleep duration is associated with blood glucose levels 13 , 33 . A limitation in these studies and our study is that physical activity related energy expenditure (EE) during pregnancy is not controlled for.…”

Section: Discussionmentioning

confidence: 99%

A prospective study of the relationships between movement and glycemic control during day and night in pregnancy

Behravesh

Fernández‐Tajes

Estampador

et al. 2021

Sci Rep

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Both disturbed sleep and lack of exercise can disrupt metabolism in pregnancy. Accelerometery was used to objectively assess movement during waking (physical activity) and movement during sleeping (sleep disturbance) periods and evaluated relationships with continuous blood glucose variation during pregnancy. Data was analysed prospectively. 15-women without pre-existing diabetes mellitus wore continuous glucose monitors and triaxial accelerometers from February through June 2018 in Sweden. The relationships between physical activity and sleep disturbance with blood glucose rate of change were assessed. An interaction term was fitted to determine difference in the relationship between movement and glucose variation, conditional on waking/sleeping. Total movement was inversely related to glucose rate of change (p < 0.001, 95% CI (− 0.037, − 0.026)). Stratified analyses showed total physical activity was inversely related to glucose rate of change (p < 0.001, 95% CI (− 0.040, − 0.028)), whereas sleep disturbance was not related to glucose rate of change (p = 0.07, 95% CI (< − 0.001, 0.013)). The interaction term was positively related to glucose rate of change (p < 0.001, 95% CI (0.029, 0.047)). This study provides temporal evidence of a relationship between total movement and glycemic control in pregnancy, which is conditional on time of day. Movement is beneficially related with glycemic control while awake, but not during sleep.

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Section: Discussionmentioning

confidence: 99%

A prospective study of the relationships between movement and glycemic control during day and night in pregnancy

Behravesh

Fernández‐Tajes

Estampador

et al. 2021

Sci Rep

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show abstract

“…Nocturnal sleep duration <7 h and later sleep midpoint were associated with statistically significant increased risk for GDM [ 26 ]. Finally, in another study short sleep duration was related to impaired glucose tolerance [ 27 ]. The findings are summarized at Table 2 .…”

Section: Introductionmentioning

confidence: 99%

“…Women with longer CPAP use showed lower rates of preterm delivery, unplanned cesarean section, and hospitalization in NICU. Redfern et al, 2019 [ 27 ] UK 49 27–30 weeks 30–40 18–40 None Actigraphy None 75-g OGTT (NICE) Shorter sleep duration was associated with impaired glucose tolerance at 2 h during the OGTT. Balserak et al, 2020 [ 33 ] USA 92 24–36 weeks All 18–42 PSQI, ESS, SASS – MVAP index, habitual snoring Type I ΑΗΙ > 5 100-g OGTT (Carpenter-Coustan) or 50-g OGTT Incidence of OSA, frequency of snoring, SASS, and duration of REM sleep were greater in GDM group.…”

Section: Introductionmentioning

confidence: 99%

Sleep disorders during pregnancy: an underestimated risk factor for gestational diabetes mellitus

Eleftheriou,

Athanasiadou,

Sifnaios

et al. 2023

Endocrine

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Sleep disorders are highly prevalent during pregnancy and significantly affect women’s health and quality of life. Gestational diabetes mellitus (GDM) is one of the most common metabolic complications during pregnancy and constitutes a significant risk factor for both mother and fetus in the short and the long term. While the association between sleep disorders and type 2 diabetes mellitus (T2DM) is indisputable, it is not clear whether there is a link between sleep disorders and GDM. The aim of this article was to investigate the association between sleep disorders and GDM and whether the treatment of sleep disorders may prevent GDM development. Insomnia, obstructive sleep apnea (OSA), restless legs syndrome (RLS), and narcolepsy were the most common sleep disorders identified during pregnancy and were related to poor sleep quality and short or prolonged sleep duration. They were all associated with an increased risk of GDM. The ideal sleep duration for pregnant women was determined at 8–9 h daily. In conclusion, sleep disorders constitute a risk factor for GDM. It is imperative that prospective studies be conducted to evaluate the effect of the early management of sleep disorders on GDM manifestation and control. Healthcare providers should highlight the importance of sufficient sleep to reinforce pregnancy outcomes.

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“…In pregnancy, epidemiological data have consistently shown strong associations between sleep quality, sleep duration, and maternal glycemia. 13,15,16 However, there is little research examining associations between other sleep disturbances, such as difficulty falling asleep and . CC-BY-NC-ND 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.…”

Section: Introductionmentioning

confidence: 99%

Mid-pregnancy sleep disturbances are not associated with mid-pregnancy maternal glycemia

Hawkins

Feghali

Abebe

et al. 2023

Preprint

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Background: In pregnancy, epidemiological data have consistently shown strong associations between sleep quality and duration and maternal glycemia. However, other sleep disturbances such as difficulty falling asleep and staying asleep are common in pregnancy. They may contribute to impaired maternal glycemia through sympathetic nervous system activity, systemic inflammation, and hormonal pathways. However, there is little research examining associations between these specific sleep disturbances and maternal glycemia. Objective: This study aimed to investigate the associations of sleep disturbances during mid-pregnancy and mid-pregnancy maternal glycemia and gestational diabetes subtypes. Study Design: This is a secondary data analysis of the Comparison of Two Screening Strategies for Gestational Diabetes trial. Participants (n = 828) self-reported the frequency of sleep disturbances (i.e., trouble falling asleep, trouble staying asleep, waking several times per night, and waking feeling tired or worn out) in mid-pregnancy. Gestational diabetes was diagnosed using either the International Associations of Diabetes and Pregnancy Study Groups or Carpenter-Coustan approach. We defined gestational diabetes subtypes based on the degree of insulin resistance and beta-cell dysfunction. We used multinomial logistic regression to examine associations of sleep disturbances with gestational diabetes status (i.e., normal, mild glycemic dysfunction, and gestational diabetes) and gestational diabetes subtypes (i.e., neither insulin resistance or beta-cell dysfunction, insulin resistance only, beta-cell dysfunction only, and insulin resistance and beta-cell dysfunction). Results: A total of 665 participants (80%) had normal glycemia, 81 (10%) mild hyperglycemia, and 80 (10%) had gestational diabetes. Among participants with gestational diabetes, 62 (78%) had both insulin resistance and beta-cell dysfunction, 15 (19 %) had insulin resistance only, and 3 had beta-cell dysfunction only or neither insulin resistance nor beta-cell dysfunction. Sleep disturbance frequency was not associated with maternal glycemia or gestational diabetes subtypes. Conclusions: Sleep disturbances in mid-pregnancy were not associated with maternal glycemia during mid-pregnancy. Future research should collect data on sleep disturbances at multiple time points in pregnancy and in combination with other sleep disturbances to determine whether sleep plays any role in maternal glycemic control.

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Objectively measured sleep duration and plasma glucose values following an oral glucose tolerance test amongst pregnant women with obesity in the UK

Abstract: Objectively measured sleep duration and plasma glucose values following an oral glucose tolerance test amongst pregnant women with obesity in the UK.

Cited by 9 publications

References 18 publications

A prospective study of the relationships between movement and glycemic control during day and night in pregnancy

A prospective study of the relationships between movement and glycemic control during day and night in pregnancy

Sleep disorders during pregnancy: an underestimated risk factor for gestational diabetes mellitus

Mid-pregnancy sleep disturbances are not associated with mid-pregnancy maternal glycemia

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