Objekttr�gerbasierte multiparametrische Zytometrie in der HNO

Gerstner, Andreas O. H.; Tárnok, Attila; Bootz, Friedrich

doi:10.1007/s00106-004-1076-2

HNO

2005

DOI: 10.1007/s00106-004-1076-2

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Objekttr�gerbasierte multiparametrische Zytometrie in der HNO

Andreas O. H. Gerstner

Attila Tárnok²,

Friedrich Bootz

Abstract: A broad spectrum of applications in clinical practice and research for the LSC is evident.

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2006

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Cited by 2 publications

References 20 publications

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Slide‐based cytometry for cytomics—A minireview

Tárnok

2006

Cytometry Pt A

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In the postgenomic era, to gain the most detailed quantitative data from biological specimens has become increasingly important in the emerging new fields of high‐content and high‐throughput single‐cell analysis for systems biology and cytomics. Areas of research and diagnosis with the demand to virtually measure “anything” in the cell include immunophenotyping, rare cell detection and characterization in the case of stem cells and residual tumor cells, tissue analysis, and drug discovery. Systemic analysis is also a prerequisite for predictive medicine by genomics, proteomics, and cytomics. This issue of Cytometry Part A is dedicated to innovative concepts of system wide single cells analysis and manipulation, new technologies, data analysis and display, and, finally, quality assessment. The manuscripts to these chapters are provided by cutting edge experts in the fields. This overview will briefly highlight the most important aspects of this continuously developing field. © 2006 International Society for Analytical Cytology

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Slide‐based cytometry for cytomics—A minireview

Tárnok

2006

Cytometry Pt A

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Cytomics – importance of multimodal analysis of cell function and proliferation in oncology

2006

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Cancer is a highly complex and heterogeneous disease involving a succession of genetic changes (frequently caused or accompanied by exogenous trauma), and resulting in a molecular phenotype that in turn results in a malignant specification. The development of malignancy has been described as a multistep process involving self-sufficiency in growth signals, insensitivity to antigrowth signals, evasion of apoptosis, limitless replicative potential, sustained angiogenesis, and finally tissue invasion and metastasis. The quantitative analysis of networking molecules within the cells might be applied to understand native-state tissue signalling biology, complex drug actions and dysfunctional signalling in transformed cells, that is, in cancer cells. High-content and high-throughput single-cell analysis can lead to systems biology and cytomics. The application of cytomics in cancer research and diagnostics is very broad, ranging from the better understanding of the tumour cell biology to the identification of residual tumour cells after treatment, to drug discovery. The ultimate goal is to pinpoint in detail these processes on the molecular, cellular and tissue level. A comprehensive knowledge of these will require tissue analysis, which is multiplex and functional; thus, vast amounts of data are being collected from current genomic and proteomic platforms for integration and interpretation as well as for new varieties of updated cytomics technology. This overview will briefly highlight the most important aspects of this continuously developing field.

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Objekttr�gerbasierte multiparametrische Zytometrie in der HNO

Abstract: A broad spectrum of applications in clinical practice and research for the LSC is evident.

Cited by 2 publications

References 20 publications

Slide‐based cytometry for cytomics—A minireview

Slide‐based cytometry for cytomics—A minireview

Cytomics – importance of multimodal analysis of cell function and proliferation in oncology

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