Abstract:contraction and for increased cardiac contractility in response to inotropic stimuli. Mutations in MYBPC3, the gene encoding cMyBP-C, are the single most common genetic cause of hypertrophic cardiomyopathy (HCM). It has been proposed that the interaction of the N-terminal domains (NTDs) of cMyBP-C (e.g. C0, C1, M and C2) with myosin heads may stabilize the super-relaxed state (SRX-state) of the thick filament, while NMR experiments directly confirmed the binding of the C0 Ig-domain of cMyBP-C to the isolated r… Show more
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