Soil-structure interaction (SSI) has gamed significant recognition of importance in the control of seismically excited structures in the past ten years. In this paper, recent developments of the SSI effect on the performance of passive, semiactive and active control strategy are summarized in general. It is followed by a short presentation on the seismic effectiveness of tuned mass dampers, variable stiffness devices and active control systems in reducing the maximum response of structures with the intent of comparing the SSI effect on various devices and control systems. Numerical studies on a 3-and a 12-story frame structure resting on a viscoelastic half space indicated that SSI tends to defeat the effectiveness of control systems. This defeat is primarily because the damping of a soil-structure system increases and the structure vibrates more like a rigid body as the soil material softens. Since nearly all devices made of smart materials either passively or actively respond to the structural deformation, their performance is likely to degrade for flexible-base structures.