Observation of a chemical reaction using a micromechanical sensor

Gimzewski, James K.; Gerber, Ch.; Meyer, Ernst; Schlittler, R. R.

doi:10.1016/0009-2614(93)e1419-h

Cited by 466 publications

(254 citation statements)

References 17 publications

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“…The response pattern of eight cantilevers was analysed with principal component analysis and artificial neural network techniques, which facilitates the application of the device as an artificial chemical nose. Single-cantilever sensors can determine quantities below the detection limits of equivalent 'classical' methods; thus, catalytic processes can be observed with picojoule sensitivity in nanocalorimetry (Gimzewski et al 1994).…”

Section: (I ) Spiderwebmentioning

confidence: 99%

Biomimetics: lessons from nature–an overview

Bhushan

2009

Phil. Trans. R. Soc. A.

1,128

733

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Nature has developed materials, objects and processes that function from the macroscale to the nanoscale. These have gone through evolution over 3.8 Gyr. The emerging field of biomimetics allows one to mimic biology or nature to develop nanomaterials, nanodevices and processes. Properties of biological materials and surfaces result from a complex interplay between surface morphology and physical and chemical properties. Hierarchical structures with dimensions of features ranging from the macroscale to the nanoscale are extremely common in nature to provide properties of interest. Molecularscale devices, superhydrophobicity, self-cleaning, drag reduction in fluid flow, energy conversion and conservation, high adhesion, reversible adhesion, aerodynamic lift, materials and fibres with high mechanical strength, biological self-assembly, antireflection, structural coloration, thermal insulation, self-healing and sensory-aid mechanisms are some of the examples found in nature that are of commercial interest. This paper provides a broad overview of the various objects and processes of interest found in nature and applications under development or available in the marketplace.

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Section: (I ) Spiderwebmentioning

confidence: 99%

Biomimetics: lessons from nature–an overview

Bhushan

2009

Phil. Trans. R. Soc. A.

1,128

733

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“…And the membrane is extremely thin with a thickness of about 5 nm. Thus, the deflection of the microcantilever can be estimated to be lower than 3.6 nm when a 1 mW cm 2 visible light illuminates the bR on the microcantilever according to [49,51]. In addition, in our experiment, the microcantilever was immersed in a liquid cell, which was mounted on a thermoelectric cooler so that the liquid in the cell was always in a thermal equilibrium.…”

Section: Properties Of the Hybrid Devicementioning

confidence: 93%

A nanomechanical device based on light-driven proton pumps

Ren¹,

Zhao²,

Han³

et al. 2006

Nanotechnology

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In this paper, a hybrid device based on a microcantilever interfaced with bacteriorhodopsin (bR) is constructed. The microcantilever, on which the highly oriented bR film is self-assembled, undergoes controllable and reversible bending when the light-driven proton pump protein, bR, on the microcantilever surface is activated by visible light. Several control experiments are carried out to preclude the influence of heat and photothermal effects. It is shown that the nanomechanical motion is induced by the resulting gradient of protons, which are transported from the KCl solution on the cytoplasmic side of the bR film towards the extracellular side of the bR film. Along with a simple physical interpretation, the microfabricated cantilever interfaced with the organized molecular film of bR can simulate the natural machinery in converting solar energy to mechanical energy.

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“…Importantly, with the miniaturization of biosensor's sensitive elements on the basis of a microfabricated cantilever -as is the case with calorimetric biosensors -the theoretical sensitivity may reach several attoJoules, i.e. the level of 10-100 molecules [91,92]. In microbalance biosensors, a theoretical minimum detectable mass of 10 215 g (i.e.…”

Section: Cd-rom and Other Biosensorsmentioning

confidence: 99%

Nanotechnologies in proteomics

Ivanov

Govorun

Быков³

et al. 2006

Proteomics

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Progress in proteomic researches is largely determined by development and implementation of new methods for the revelation and identification of proteins in biological material in a wide concentration range (from 10 23 M to single molecules). The most perspective approaches to address this problem involve (i) nanotechnological physicochemical procedures for the separation of multicomponent protein mixtures; among these of particular interest are biospecific nanotechnological procedures for selection of proteins from multicomponent protein mixtures with their subsequent concentration on solid support; (ii) identification and counting of single molecules by use of molecular detectors. The prototypes of biospecific nanotechnological procedures, based on the capture of ligand biomolecules by biomolecules of immobilized ligate and the concentration of the captured ligands on appropriate surfaces, are well known; these are affinity chromatography, magnetic biobeads technology, different biosensor methods, etc. Here, we review the most promising nanotechnological approaches for selection of proteins and kinetic characterization of their complexes based on these biospecific methods with subsequent MS/MS identification of proteins and protein complexes. Two major groups of methods for the analysis and identification of individual molecules and their complexes by use of molecular detectors will be reviewed: scanning probe microscopy (SPM) (including atomic-force microscopy) and cryomassdetector technology.

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Observation of a chemical reaction using a micromechanical sensor

Cited by 466 publications

References 17 publications

Biomimetics: lessons from nature–an overview

Biomimetics: lessons from nature–an overview

A nanomechanical device based on light-driven proton pumps

Nanotechnologies in proteomics

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