Observation of a Lymphatic Pump in a Human by Using Photoacoustic Imaging

Suzuki, Yushi; Kajita, Hiroki; Imanishi, Nobuaki; Aiso, Sadakazu; Kishi, Kazuo

doi:10.1097/gox.0000000000002914

Cited by 6 publications

(4 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The authors in [78] compared the images obtained with OAI and near infrared optical imaging of the lymphatic vessels in the lower limbs of 15 subjects using ICG, demonstrating that OAI obtained a more detailed 3D representation of the lymphatic vessels. A human lymphatic pump was observed using ICG contrast and OAI in [79], where the lymphatic fluid did not flow continuously. The study was included in the Japan registry of clinical trials (JRCTs032180204).…”

Section: Lymphatic System Imagingmentioning

confidence: 99%

“…The study was included in the Japan registry of clinical trials (JRCTs032180204). Other research efforts were oriented to [80] study the effect of aging on the lymphatic vessels in the lower leg of 19 subjects enrolled in the clinical record of [79], concluding that the number of lymphatic vessels increased with age (Figure 3c). In [81] the team evaluated the surgical procedure called lymphaticovenular anastomosis [82] using the system with a new implementation for OAI lymphangiography.…”

Section: Lymphatic System Imagingmentioning

confidence: 99%

See 1 more Smart Citation

A Review on Clinical Optoacoustic Imaging: Are We Close to Clinical Adoption?

Contador,

Ripoll,

Lage

et al. 2024

Preprint

View full text Add to dashboard Cite

Optoacoustic imaging is an emerging technology that holds great promise for improving general clinical practice since it offers a unique combination of optical absorption contrast, high resolution, and high penetration depth. This combination of factors provides a distinct advantage over alternative imaging modalities in oncology, cardiology, dermatology, or endocrinology among other medical fields. Optoacoustic technology affords the medical practitioner the possibility of visualizing light-absorbing biomolecules like water, lipids, oxy/deoxy hemoglobin, or melanin in deep tissue with relatively cheap and small form factor instruments, without the need of contrast agents or ionizing radiation. Moreover, exogenous fluorescent contrast agents like indocyanine green or methylene blue can also be observed. Driven by its potential for new applications in the clinic, the field has experienced intense changes in the last 20 years. Continuous technological advancements in instrumentation, image formation methods, or acquisition geometries, have led to the development of numerous clinical devices also motivating the creation of several startup companies that aim to translate the technology from the lab to the clinic. Thus, the question arises: how far are we from clinical adoption? In this article, we aim to shed light on such question by reviewing the clinical studies that have been performed in the last 10 years. Our intention is to go beyond the classical review format by providing a brief general overview of the steps that new imaging methods undergo on their journey from the lab to clinical adoption. Then we examine the progress that optoacoustic technology has made on such a journey.

show abstract

Section: Lymphatic System Imagingmentioning

confidence: 99%

Section: Lymphatic System Imagingmentioning

confidence: 99%

A Review on Clinical Optoacoustic Imaging: Are We Close to Clinical Adoption?

Contador,

Ripoll,

Lage

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…56 The imaging system (PAL, photoacoustic lymphangiography) enabled the differentiation of lymphatic vessels from blood vessels by assigning different color codes. 57,58 (►Fig. 8).…”

Section: Clinical Imaging Of Lymphatic Vesselsmentioning

confidence: 99%

“… 59 Both PAI devices use ICG as a contrast medium for demonstrating lymphatic vessels and simultaneously obtaining 3D images of the vein. 57 58 60 The outstanding features of PAL allow direct observation of lymphaticovenous anastomosis anastomosis and postoperative patency. However, PAI can degrade image quality in areas with thick subcutaneous tissue commonly seen in patients with lymphedema due to light penetration.…”

Section: Lymphatic Systemmentioning

confidence: 99%

Evolution of Anatomical Studies on the Arterial, Venous, and Lymphatic System in Plastic Surgery

et al. 2022

View full text Add to dashboard Cite

Anatomies of the vascular and lymphatic systems have been vital research topics in reconstructive surgery. Harvey was a pioneer who provided the earliest descriptions of the cutaneous vasculature in the 17th century. The concept of vascular territories of the skin was first described by Manchot. The radiographic injection method in cadavers was developed by Salman, who defined more than 80 vascular territories. The arterial system has been thoroughly investigated with the development of regional and free flaps. The concept of axial and random pattern flaps was introduced by McGregor and Morgan. Manchot's vascular territories were refined by Taylor and Palmer as the angiosome concept. Detailed information about the venous circulation is essential for reconstructive surgeries. The concept of intrinsic and extrinsic venocutaneous vascular systems was introduced by Nakajima and led to the development of the venoadipofascial flap. The importance of venous augmentation in flap survival was emphasized by Chang. The lymphatic system was discovered much later than the arterial and venous systems. Aselli was credited for discovering the lacteal vessels in the 17th century; mercury was popularly used as a contrast agent to distinguish lymphatic vessels for the next three centuries. A radiographic method in cadavers was developed by Suami. Lymphatic imaging devices are constantly upgrading, and photoacoustic imaging was recently introduced for three-dimensional visualization of architecture of superficial layers of the lymphatic and venous systems.

show abstract

Evaluation of Postoperative Anastomotic Patency in Lymphaticovenular Anastomosis Using Photoacoustic Imaging

Suzuki,

Kajita,

Otaki

et al. 2024

Journal of Surgical Oncology

View full text Add to dashboard Cite

Background and ObjectivesLymphaticovenular anastomosis (LVA) is a surgical technique used to alleviate lymphedema by bypassing the lymphatic and venous vessels and facilitating lymphatic fluid drainage. Accurate evaluation of anastomotic patency is crucial for assessing LVA outcomes. Traditional near‐infrared fluorescence lymphography has limitations, including fluorescence diffusion in subcutaneous fat and difficulty evaluating areas beneath the dermal backflow. Photoacoustic imaging (PAI) is a potential alternative for high‐resolution visualization of lymphatic and blood vessels. We aimed to evaluate the utility of PAI for assessing LVA patency.MethodsUsing the LUB0 PAI system, we examined patients who underwent LVA. Imaging was conducted using subcutaneously injected indocyanine green (ICG) to visualize lymphatic vessels.ResultsResults showed clear patency in some cases, inability to evaluate it in others, and confirmed occlusion in certain instances.ConclusionsWhile PAI provides valuable insights, challenges remain, including the potential for ambiguous results from the intermittent nature of lymphatic flow and difficulty visualizing low‐ICG‐concentration lymphatic vessels. Nonetheless, PAI offers a promising method for detailed 3D evaluation of anastomoses. It may improve surgical outcomes and contribute to future evidence in the field. Further advancements, including real‐time video assessment, may enhance the accuracy and reliability of LVA patency evaluation.

show abstract

Observation of a Lymphatic Pump in a Human by Using Photoacoustic Imaging

Cited by 6 publications

References 6 publications

A Review on Clinical Optoacoustic Imaging: Are We Close to Clinical Adoption?

A Review on Clinical Optoacoustic Imaging: Are We Close to Clinical Adoption?

Evolution of Anatomical Studies on the Arterial, Venous, and Lymphatic System in Plastic Surgery

Evaluation of Postoperative Anastomotic Patency in Lymphaticovenular Anastomosis Using Photoacoustic Imaging

Contact Info

Product

Resources

About