2021
DOI: 10.1007/s00216-021-03452-y
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Observation of charged droplets from electrospray ionization (ESI) plumes in API mass spectrometers

Abstract: Electrospray ionization (ESI) generates bare analyte ions from charged droplets, which result from spraying a liquid in a strong electric field. Experimental observations available in the literature suggest that at least a significant fraction of the initially generated droplets remain large, have long lifetimes, and can thus aspirate into the inlet system of an atmospheric pressure ionization mass spectrometer (API-MS). We report on the observation of fragment signatures from charged droplets penetrating deep… Show more

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Cited by 14 publications
(13 citation statements)
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“…There is also evidence that electrospray ionization generates ''molecular asteroids'' -relatively large, highly-charged droplets comprised of the analyte and the ESI solvent -which survive transit through the DMS cell and pass into the mass spectrometer. 151,152 Could these molecular asteroids be used to study a ''fully solvated'' ion using gas-phase techniques? Interested readers are directed to work of Benter, Cooper, Donald, Glover, Shvartsburg, and Smith for additional information.…”
Section: What Else Can We Learn From Dms?mentioning
confidence: 99%
“…There is also evidence that electrospray ionization generates ''molecular asteroids'' -relatively large, highly-charged droplets comprised of the analyte and the ESI solvent -which survive transit through the DMS cell and pass into the mass spectrometer. 151,152 Could these molecular asteroids be used to study a ''fully solvated'' ion using gas-phase techniques? Interested readers are directed to work of Benter, Cooper, Donald, Glover, Shvartsburg, and Smith for additional information.…”
Section: What Else Can We Learn From Dms?mentioning
confidence: 99%
“…The significant difference between HESI and IR-MALDI is the higher number of protons in the HESI droplets. 90 The average initial droplet size was found to be the same for ESI and IR-MALDI (see S.5 in the SI †) while droplets generated by IR-MALDI show a broader size distribution.…”
Section: Biv the Influence Of Charged Dropletsmentioning
confidence: 88%
“…This is in stark contrast to reported experimental observations made by different groups and with different analyte and solvent systems. Markert et al and Cole give an overview of some of these experimentally determined droplet sizes. The reported sizes vary in a surprisingly large range between 2 and 100 μm.…”
Section: Introductionmentioning
confidence: 99%
“…The latter, however, is described repeatedly in the literature. 7,31−34 Based on the work of Kang et al, 35 Markert et al 25 demonstrate that large amounts of charged droplets penetrate the high vacuum region of different mass spectrometers (SCIEX triple quadrupole with Q-Jet interface, Bruker amaZon QIT, and Agilent Q-ToF). It was shown that droplet presence in the analyzer region of mass spectrometers is most likely not an edge case of some instruments under special conditions but a general phenomenon.…”
Section: ■ Introductionmentioning
confidence: 99%