“…The isolation of several R genes involved in diverse plantpathogen interactions, conferring resistance to fungi, bacteria, viruses, and nematodes (Bent, 1996;Baker et al, 1997;Hammond-Kosack and Jones, 1997), has revealed four related but distinct classes of predicted R proteins that confer resistance conforming to Flor's gene-for-gene hypothesis. These R genes from tomato, tobacco, rice, flax, and Arabidopsis encode proteins that share one or more similar motifs: leucine-rich repeat (LRR) and Toll/interleukin/resistance (TIR) regions (implicated in protein-protein interactions), nucleotide binding sites (NBSs), and protein kinase domains (implicated in signaling).…”