Observation of Hydrofluoric Acid Burns on Osseous Tissues by Means of Terahertz Spectroscopic Imaging

Baughman, William; Yokus, H.; Balci, Soner; Wilbert, David S.; Kung, Patrick; Kim, S. M.

doi:10.1109/tthz.2013.2267416

Cited by 12 publications

(5 citation statements)

References 23 publications

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“…Alternatively, denoising can be implemented with the algorithms based on the Hilbert-Huang transform [219], such as the mean estimation empirical mode decomposition method (ME-EMD) [220], with no need to choose the decomposition basis. Denoising techniques accompany the analysis of raw THz pulses in the algorithms of malignancy diagnosis as well [221].…”

Section: Data Processing In Terahertz Pulsed Spectroscopymentioning

confidence: 99%

“…For example, one can apply a double Gaussian filter to the suppression of high-and low-frequency noises [214], or Wiener filtering [224], which can be supplemented with the additional wavelet-domain filtering of a pulse response function [214]. This method is quite simple and with adequate filtering, provides a good contrast between tissues in combination with a high processing rate [214,221,[225][226][227]. It is rather common for the study of neoplasms; see for example [228].…”

Section: Data Processing In Terahertz Pulsed Spectroscopymentioning

confidence: 99%

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The progress and perspectives of terahertz technology for diagnosis of neoplasms: a review

Zaytsev

Dolganova

Chernomyrdin

et al. 2019

J. Opt.

164

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Over the past few decades, significant attention has been paid to the biomedical applications of terahertz (THz) technology. Nowadays, THz spectroscopy and imaging have allowed numerous demanding problems in the biological, medical, food, plant and pharmaceutical sciences to be solved. Among the biomedical applications, the label-free diagnosis of malignant and benign neoplasms represents one of the most attractive branches of THz technology. Despite this attractiveness, THz diagnosis methods are still far from being ready for use in medical practice. In this review, we consider modern research results in the THz diagnosis of malignant and benign neoplasms, along with the topical research and engineering problems which restrain the translation of THz technology to clinics. We start by analyzing the common models of THz-wave-tissue interactions and the effects of tissue exposure to THz waves. Then, we discuss the existing modalities of THz spectroscopic and imaging systems, which have either already been applied in medical imaging, or hold strong potential. We summarize the earlier-reported and original results of the THz measurements of neoplasms with different nosology and localization. We pay attention to the origin of contrast between healthy and pathological tissues in the THz spectra and images, and discuss the prospects of THz technology in

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Section: Data Processing In Terahertz Pulsed Spectroscopymentioning

confidence: 99%

Section: Data Processing In Terahertz Pulsed Spectroscopymentioning

confidence: 99%

The progress and perspectives of terahertz technology for diagnosis of neoplasms: a review

Zaytsev

Dolganova

Chernomyrdin

et al. 2019

J. Opt.

164

View full text Add to dashboard Cite

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“…Terahertz radiation sources have gleaned much attention due to the wide range of potential applications of such devices, such as high data rate communications; the identification of concealed weaponry; remote, high-resolution imaging; and biomedical diagnostics [1][2][3][4][5]. Several existing technologies to generate terahertz waves are currently available, including quantum cascade lasers, solid state electron devices, and optical devices [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Theoretical Study of a 0.22 THz Backward Wave Oscillator Based on a Dual-Gridded, Carbon-Nanotube Cold Cathode

et al. 2018

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The carbon nanotube (CNT) cold cathode is an attractive choice for millimeter and terahertz vacuum electronic devices owning to its unique instant switch-on and high emission current density. A novel, dual-gridded, field emission architecture based on a CNT cold cathode is proposed here. CNTs are synthesized directly on the cathode surface. The first separating grid is attached to the CNT cathode surface to shape the CNT cathode array. The second separating grid is responsible for controlled extraction of electrons from the CNT emitters. The cathode surface electric field distribution has been improved drastically compared to conventional planar devices. Furthermore, a high-compression-ratio, dual-gridded, CNT-based electron gun has been designed to further increase the current density, and a 21 kV/50 mA electron beam has been obtained with beam transparency of nearly 100%, along with a compression ratio of 39. A 0.22 THz disk-loaded waveguide backward wave oscillator (BWO) based on this electron gun architecture has been realized theoretically with output power of 32 W. The results indicate that higher output power and higher frequency terahertz BWOs can be made using advanced, nanomaterial-based cold cathodes.

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“…All the methods to noninvasively diagnose skin cancers [37]- [40], [60], [61] and burns [56]- [59] based on THz absorption spectroscopy, as well as all the approaches for principal component analysis [40], [60], should be adjusted to account for the variations of the THz refractive index and absorption coefficient along the human body.…”

Section: Measuring the Variation Of Refractive Index And Absorbtimentioning

confidence: 99%

“…The ability to cause favorable changes in the expression of genes indicates prospectives of therapeutic applications of THz radiation. The use of TPS for sensing in corneal tissue [50], dental tissue [51], [52], and blood [53]- [55], as well as for studying thermal and chemical tissue burns [56]- [59], has been studied. In [60] and [61], the ability to noninvasively diagnose dysplastic skin nevi has been demonstrated; this is of importance since the dysplasia of skin nevi is considered to be a melanoma precursor, which is reportedly the most dangerous skin cancer [62], [63].…”

Section: Introductionmentioning

confidence: 99%

Highly Accurate in Vivo Terahertz Spectroscopy of Healthy Skin: Variation of Refractive Index and Absorption Coefficient Along the Human Body

Zaytsev

Gavdush

Chernomyrdin

et al. 2015

IEEE Trans. THz Sci. Technol.

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A method to reconstruct the terahertz (THz) refractive index and absorption coefficient of in vivo tissue using THz pulsed spectroscopy (TPS) has been proposed. The method utilizes a reference THz window to fix the sample of interest during the TPS reflection mode measurements. Satellite pulses caused by multiple THz-wave reflections in the reference window are taken into account to accurately solve the inverse problem. The stability of the proposed method in the presence of various factors, including digital noise in the TPS waveforms and fluctuations of the reference THz window position, has been accurately analyzed. The method has been implemented to study in vivo the THz refractive index and absorption coefficient of the human skin. The skin from three persons has been measured, and the results agree with the well-known data on healthy skin spectroscopy in general, except for several regions of the skin. Thus, for the elbow, the hand, the knee, and the heel the THz refractive index and absorption coefficient considerably differ from the average values. The observed results are of principle importance for further development of novel approaches to skin diagnosis based on THz technologies.Index Terms-Absorption coefficient, inverse problem, material parameters, refractive index, spectroscopy of the skin, terahertz pulsed spectroscopy, THz technology.

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Observation of Hydrofluoric Acid Burns on Osseous Tissues by Means of Terahertz Spectroscopic Imaging

Cited by 12 publications

References 23 publications

The progress and perspectives of terahertz technology for diagnosis of neoplasms: a review

The progress and perspectives of terahertz technology for diagnosis of neoplasms: a review

Theoretical Study of a 0.22 THz Backward Wave Oscillator Based on a Dual-Gridded, Carbon-Nanotube Cold Cathode

Highly Accurate in Vivo Terahertz Spectroscopy of Healthy Skin: Variation of Refractive Index and Absorption Coefficient Along the Human Body

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