We propose and experimentally demonstrate an optical millimeter‐wave and sub‐terahertz signal generation method based on frequency 18‐tupling using a power amplifier, an optical modulator, and a semiconductor optical amplifier (SOA). The power amplifier is operated in the nonlinear region and generates a third‐order harmonic frequency. Next, frequency doubling by optical carrier suppression using the optical modulator is performed. Four‐wave mixing of the SOA and optical filtering produce two‐tone waves whose frequency spacing corresponds to 18‐tupling of the input RF frequency. The experimental results show that two idlers could be obtained at 1549.98 and 1550.85 nm in the wavelength domain corresponding to the beat frequency of 108 GHz from the 6 GHz RF signal. Because of the bandwidth limitations of our available photodetectors, the phase noise of the beat signal is measured at a lower frequency of 60 GHz for the input of 3.3 GHz and is −74.60 dBc/Hz at an offset of 100 kHz. © 2013 Wiley Periodicals, Inc. Microwave Opt Technol Lett 55:1677–1680, 2013; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.27605