We present a theoretical review of the recent progress in non-equilibrium BCS (Bardeen-Cooper-Schrieffer)-BEC (Bose-Einstein condensation) crossover physics. As a paradigmatic example, we consider a strongly interacting driven-dissipative two-component Fermi gas where the non-equilibrium steady state is tuned by adjusting the chemical potential difference between two reservoirs that are coupled with the system. As a powerful theoretical tool to deal with this system, we employ the Schwinger-Keldysh Green’s function technique. We systematically evaluate the superfluid transition, as well as the single-particle properties, in the non-equilibrium BCS-BEC crossover region, by adjusting the chemical potential difference between the reservoirs and the strength of an s-wave pairing interaction associated with a Feshbach resonance. In the weak-coupling BCS side, the chemical potential difference is shown to imprint a two-step structure on the particle momentum distribution, leading to an anomalous enhancement of pseudogap, as well as the emergence of exotic Fulde-Ferrell-Larkin-Ovchinnikov-type superfluid instability. Since various non-equilibrium situations have recently been realized in ultracold Fermi gases, the theoretical understanding of non-equilibrium BCS-BEC crossover physics would become increasingly important in this research field.