Observational prospective cohort study of patients with newly-diagnosed ocular sebaceous carcinoma

Abstract

This population-based prospective study confirms OSC as a rare cancer in the UK. Masquerade syndromes result in significant diagnostic delays and increase the risk of pagetoid tumour spread. There is considerable UK variation in pathological and surgical management, and ocular reconstruction and radical surgery is often required for OSC due to delayed presentation.

Sebaceous carcinoma in Japanese patients: clinical presentation, staging and outcomes

“…The rate of intraepithelial spread within previous studies involving predominantly Caucasian patients has been reported as high as 51%, and these studies have suggested that map biopsies of the palpebral and bulbar conjunctiva should be performed routinely for sebaceous carcinomas 2 9 15. However, we found much lower rates, with just 21% of our cases demonstrating pagetoid spread histologically.…”

“…A recent study from the UK estimated that the annual incidence was 0.41/million population 2. Higher rates have been demonstrated in Asia where sebaceous carcinomas have been shown to account for up to 37% of all malignant eye tumours 3–5.…”

Sebaceous gland carcinoma of the eyelid: clinicopathological features and outcome in Asian Indians

“…2 In the United Kingdom, the estimated annual incidence is 0.41 cases per million population. 3 In the Asian-Indian population, eyelid SGC is a relatively common eyelid malignancy accounting for 28-60% cases of all eyelid malignancies. 2,4,5 Eyelid SGC is an aggressive tumor causing metastasis-related mortality in 3-41%.…”

Recent Advances in Ophthalmic Plastic Surgery

“…Krema and associates 99 found 94% cure rate in a series of 90 such patients. 102 Masquerade syndromes result in significant diagnostic delays and increase the risk of pagetoid tumor spread. 100 The need for exenteration for BCC may be significantly higher when the lesion involves a medial canthal location; initial management does not include margincontrolled excision, or pathologic analysis reveals an infiltrative subtype.…”

“…Orbital exenteration was needed in 5.5% of 506 patients in a large series of BCCs managed at the Orbital Unit of the University of Naples, Italy. 102 There is considerable variation in the pathological features and surgical management in the United Kingdom, and ocular reconstruction and radical surgery are often required due to delayed presentation. 100 Sebaceoma is a benign sebaceous tumor that has been well characterized in the dermatologic literature and may have systemic implications.…”