Observational retrospective study calculating health service costs of patients receiving surgery for chronic rhinosinusitis in England, using linked patient-level primary and secondary care electronic data

Abstract

ObjectivesChronic rhinosinusitis (CRS) symptoms are experienced by an estimated 11% of UK adults, and symptoms have major impacts on quality of life. Data from UK and elsewhere suggest high economic burden of CRS, but detailed cost information and economic analyses regarding surgical pathway are lacking. This paper estimates healthcare costs for patients receiving surgery for CRS in England.DesignObservational retrospective study examining cost of healthcare of patients receiving CRS surgery.SettingLinked electronic health records from the Clinical Practice Research Datalink, Hospital Episode Statistics and Office for National Statistics databases in England.ParticipantsA phenotyping algorithm using medical ontology terms identified ‘definite’ CRS cases who received CRS surgery. Patients were registered with a general practice in England. Data covered the period 1997–2016. A cohort of 13 462 patients had received surgery for CRS, with 9056 (67%) having confirmed nasal polyps.Outcome measuresInformation was extracted on numbers and types of primary care prescriptions and consultations, and inpatient and outpatient hospital investigations and procedures. Resource use was costed using published sources.ResultsTotal National Health Service costs in CRS surgery patients were £2173 over 1 year including surgery. Total costs per person-quarter were £1983 in the quarter containing surgery, mostly comprising surgical inpatient care costs (£1902), and around £60 per person-quarter in the 2 years before and after surgery, of which half were outpatient costs. Outpatient and primary care costs were low compared with the peak in inpatient costs at surgery. The highest outpatient expenditure was on CT scans, peaking in the quarter preceding surgery.ConclusionsWe present the first study of costs to the English healthcare system for patients receiving surgery for CRS. The total aggregate costs provide a further impetus for trials to evaluate the relative benefit of surgical intervention.

Exploring Endotypes in Chronic Rhinosinusitis (ExpRess): Protocol for a cohort study

“…This work may lay the groundwork for future studies to predict which patients might respond to medical or surgical therapy. Patients undergoing surgery for CRS in the UK can have treatment costs totalling >£2,000 per year, compared to macrolide antibiotics prescriptions costing <£10/year [9]. In a retrospective study of 88,317 patient with CRS, 46% were prescribed antibiotics for CRS and 26% had more than 10 recorded prescriptions during follow up, suggesting that CRS is a significant target for antibiotic stewardship PLOS ONE [10].…”