Observational Study of <i>ChondroT's</i> Improvement of Blood Metabolites in High-fat Diet-induced Hyperlipidemia

Yoon, Chan Suk; Kim, Do hyeong; Na, Chang Su; Jeong, Ji Won; Kim, Ji Hoon; Kim, Sun Gil; Choi, Ji Min; Kim, Seon Jong

doi:10.18325/jkmr.2021.31.1.81

J Korean Med Rehabil

2021

DOI: 10.18325/jkmr.2021.31.1.81

|View full text |Cite

Observational Study of ChondroT's Improvement of Blood Metabolites in High-fat Diet-induced Hyperlipidemia

Chan Suk Yoon

Do hyeong Kim

Chang Su Na

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Anti-Obesity and Anti-Diabetic Effects of Ostericum koreanum (Ganghwal) Extract

Lee,

Nam

2024

IJMS

View full text Add to dashboard Cite

“Ganghwal” is a widely used herbal medicine in Republic of Korea, but it has not been reported as a treatment strategy for obesity and diabetes within adipocytes. In this study, we determined that Ostericum koreanum extract (OKE) exerts an anti-obesity effect by inhibiting adipogenesis and an anti-diabetic effect by increasing the expression of genes related to glucose uptake in adipocytes and inhibiting α-glucosidase activity. 3T3-L1 preadipocytes were differentiated for 8 days in methylisobutylxanthine, dexamethasone, and insulin medium, and the effect of OKE was confirmed by the addition of 50 and 100 µg/mL of OKE during the differentiation process. This resulted in a reduction in lipid accumulation and the expression of PPARγ (Peroxisome proliferator-activated receptor γ) and C/EBPα (CCAAT enhancer binding protein α). Significant activation of AMPK (AMP-activated protein kinase), increased expression of GLUT4 (Glucose Transporter Type 4), and inhibition of α-glucosidase activity were also observed. These findings provide the basis for the anti-obesity and anti-diabetic effects of OKE. In addition, OKE has a significant antioxidant effect. This study presents OKE as a potential natural product-derived material for the treatment of patients with metabolic diseases such as obesity- and obesity-induced diabetes.

show abstract

Anti-Obesity and Anti-Diabetic Effects of Ostericum koreanum (Ganghwal) Extract

Lee,

Nam

2024

IJMS

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Observational Study of ChondroT's Improvement of Blood Metabolites in High-fat Diet-induced Hyperlipidemia

Cited by 1 publication

References 47 publications

Anti-Obesity and Anti-Diabetic Effects of Ostericum koreanum (Ganghwal) Extract

Anti-Obesity and Anti-Diabetic Effects of Ostericum koreanum (Ganghwal) Extract

Contact Info

Product

Resources

About