Developing a method for secure sequestration of anthropogenic carbon dioxide in geological formations is one of our most pressing global scientific problems. Injection into deep-sea basalt formations provides unique and significant advantages over other potential geological storage options, including (i) vast reservoir capacities sufficient to accommodate centuries-long U.S. production of fossil fuel CO2 at locations within pipeline distances to populated areas and CO2 sources along the U.S. west coast; (ii) sufficiently closed water-rock circulation pathways for the chemical reaction of CO2 with basalt to produce stable and nontoxic (Ca 2؉ , Mg 2؉ , Fe 2؉ )CO3 infilling minerals, and (iii) significant risk reduction for post-injection leakage by geological, gravitational, and hydrate-trapping mechanisms. CO2 sequestration in established sediment-covered basalt aquifers on the Juan de Fuca plate offer promising locations to securely accommodate more than a century of future U.S. emissions, warranting energized scientific research, technological assessment, and economic evaluation to establish a viable pilot injection program in the future.climate change ͉ ocean crust ͉ climate mitigation ͉ fossil fuel emissions ͉ energy I n recent years, the debate over the most effective means to stabilize greenhouse gas concentrations in the atmosphere has not focused on a single solution but has endorsed multiple approaches to this global problem that require a variety of technologies (1-4). In its latest report on carbon capture and storage, the Intergovernmental Panel on Climate Change (5) noted that geological storage of industrial CO 2 emissions can contribute significantly to achieving a stable solution over the next several decades. Among geological storage techniques, CO 2 injection into deep saline aquifers, or its reinjection into depleted oil and gas reservoirs, has potentially large storage capacity and geographic ubiquity (6-10). The effectiveness of these methods for CO 2 sequestration depends strongly on the reservoir capacity, retention time, stability, and risk for leakage (11,12). Gunter et al. (13) discuss two primary trapping mechanisms for CO 2 injected into an aquifer: physical trapping and geochemical trapping. The first involves low-permeability caprocks or stratigraphic seals that physically impede vertical migration of injected CO 2 to the surface. Sedimentary aquifers, such as depleted oil reservoirs, offer established reservoirs for physical trapping, but generally lack geochemical trapping potential. Geochemical trapping (13), also known as mineral trapping, involves long-term reactions of CO 2 with host rocks and the formation of stable minerals such as carbonates under in situ conditions. In nature, mineral carbonization of host rocks occurs in a variety of well documented settings, such as hydrothermal alteration at volcanic springs (14), through surface weathering (15), and in deep ocean vent systems (16). These processes are commonly associated with serpentinization in ultramafic and mafic roc...