Observations on Contagious Venereal Tumours in Canine Patients

Hobday, Frederick

doi:10.1016/s0372-5545(17)70080-6

Cited by 2 publications

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“…The earliest known record of CTVT is from London in 1810, where it was noted as one of only two cancers known to afflict dogs [ 23 ]. We found evidence that CTVT was present prior to 1910 in the United States [ 24 ],[ 25 ], France [ 26 ], Germany [ 27 ]-[ 33 ], Italy [ 34 ], the United Kingdom [ 2 ],[ 4 ],[ 6 ],[ 35 ]-[ 37 ], Japan [ 38 ] and Papua New Guinea [ 39 ]. A 1906 report from Papua New Guinea stated that CTVT was “endemic before the advent of the white man” [ 39 ].…”

Section: Resultsmentioning

confidence: 99%

The changing global distribution and prevalence of canine transmissible venereal tumour

Strakova

Murchison

2014

BMC Vet Res

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BackgroundThe canine transmissible venereal tumour (CTVT) is a contagious cancer that is naturally transmitted between dogs by the allogeneic transfer of living cancer cells during coitus. CTVT first arose several thousand years ago and has been reported in dog populations worldwide; however, its precise distribution patterns and prevalence remain unclear.ResultsWe analysed historical literature and obtained CTVT prevalence information from 645 veterinarians and animal health workers in 109 countries in order to estimate CTVT’s former and current global distribution and prevalence. This analysis confirmed that CTVT is endemic in at least 90 countries worldwide across all inhabited continents. CTVT is estimated to be present at a prevalence of one percent or more in dogs in at least 13 countries in South and Central America as well as in at least 11 countries in Africa and 8 countries in Asia. In the United States and Australia, CTVT was reported to be endemic only in remote indigenous communities. Comparison of current and historical reports of CTVT indicated that its prevalence has declined in Northern Europe, possibly due to changes in dog control laws during the nineteenth and twentieth centuries. Analysis of factors influencing CTVT prevalence showed that presence of free-roaming dogs was associated with increased CTVT prevalence, while dog spaying and neutering were associated with reduced CTVT prevalence. Our analysis indicated no gender bias for CTVT and we found no evidence that animals with CTVT frequently harbour concurrent infectious diseases. Vincristine was widely reported to be the most effective therapy for CTVT.ConclusionsOur results provide a survey of the current global distribution of CTVT, confirming that CTVT is endemic in at least 90 countries worldwide. Additionally, our analysis highlights factors that continue to modify CTVT’s prevalence around the world and implicates free-roaming dogs as a reservoir for the disease. Our analysis also documents the disappearance of the disease from the United Kingdom during the twentieth century, which appears to have been an unintentional result of the introduction of dog control policies.

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Section: Resultsmentioning

confidence: 99%

The changing global distribution and prevalence of canine transmissible venereal tumour

Strakova

Murchison

2014

BMC Vet Res

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“…The first report of CTVT in the UK was in 1810, when it was mentioned as one of only two cancers known to affect dogs (the other was mammary cancer) 13 . In the early 20th century, the disease gained prominence as an experimental cancer model, 14 while outbreaks in breeding kennels caused occasional consternation 15 . However, its scientific interest had been largely forgotten by the middle of the century, and sporadic reports from the 1950s and 1960s suggest that CTVT cases were rare 16,17 .…”

Section: Figurementioning

confidence: 99%

Rising incidence of canine transmissible venereal tumours in the UK

Murchison

2021

Veterinary Record

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Observations on Contagious Venereal Tumours in Canine Patients

Cited by 2 publications

References 0 publications

The changing global distribution and prevalence of canine transmissible venereal tumour

The changing global distribution and prevalence of canine transmissible venereal tumour

Rising incidence of canine transmissible venereal tumours in the UK

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