Observations on Growth (Chondrotrophic) Hormone and Localization of Its Point of Attack

Freud, J.; Levie, L. H.; Kroon, Daniëlle

doi:10.1677/joe.0.0010056

Cited by 46 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The growth, histology and Na,35S04-labelling in vivo and in vitro of cartilage are subject to a variety of hormonal influences. The histological (Freud, Levie & Kroon, 1939;Ingalls & Hayes, 1941 ;Ray, Evans & Becks, 1941) and autoradiographic (Dziewiatkowski, 1964) features of epiphyseal cartilage in hypophysectomized animals are not dissimilar to our findings and are reversed by growth hormone. It has been shown that growth hormone does not act directly on cartilage to stimulate sulphate uptake into mucopolysaccharides but that this activity is mediated by growth hormone-dependent growth factors termed somatomedins (Salmon & Daughaday, 1957;Chochinov & Daughaday, 1976).…”

Section: Discussionsupporting

confidence: 55%

The histology and in vivo sulphate uptake of epiphyseal cartilage in protein-depleted rats

Shapiro

Pimstone

1977

Br J Nutr

View full text Add to dashboard Cite

1. Weanling rats, aged 21 d, given a 40 g casein/kg diet for 25 d were compared with 'age-matched' controls given a 200 g casein/kg diet and with 'weight-matched' weanling controls.2. The protein-malnourished rats demonstrated failure of weight gain and linear growth, hypoproteinaemia, hypoalbuminaemia and fatty liver.3. Autoradiography of the tibia was carried out 24 h after intraperitoneal injection of Na,%Od (0.1, 1-0, 2.0, 5, 10 pCi/g body-weight). Sections of tibia, humerus and costochondral junction were stained by haematoxylin and eosin, resorcin-crystal violet and picro-fuchsin, Alcian Blue at pH 0.1 and pH 23, Alcian Blue at pH 5.7 with magnesium chloride (0.1, 0.7, 1.0 M), and by Alcian Blue after ovine testicular hyaluronidase (EC 3.2.1.35) digesti0n.T he width of the upper tibial epiphysis was measured and the histological and histochemical features of the epiphyses studied.4. The incorporation of s6S04 into the epiphyses of the protein-malnourished animals was markedly reduced. The chondrocytes were small and flattened with frequent pyknotic nuclei. The staining characteristics of the cartilagenous matrix was qualitatively similar in all animals. The epiphyses in malnutrition were found to be thin, all zones being affected. The upper tibial epiphyses (mean k SD; pm) were 202 k 46 for the protein-malnourished animals, 367 52 for age-matched controls and 578 k 40 for weight-matched controls.5. The changes found resemble those after hypophysectomy and the possible hormonal factors are discussed.

show abstract

Section: Discussionsupporting

confidence: 55%

The histology and in vivo sulphate uptake of epiphyseal cartilage in protein-depleted rats

Shapiro

Pimstone

1977

Br J Nutr

View full text Add to dashboard Cite

show abstract

“…As reported previously [Freud and Levie, 1938;Freud, Kroon, and Levie, 1939 ;Levie, 1939] the point of action of the pituitary growth hormone is shown to be the epiphyseal junction. When, therefore, the action of growth hormone is altered by oestrogens, this should manifest itself by a disturbance in bone development.…”

Section: Disturbance Of Growth By Diethylstilboestrol 423supporting

confidence: 64%

Disturbance of Growth by Diethylstilboestrol and Oestrone

Gaarenstroom¹,

Levie²

1939

Journal of Endocrinology

Self Cite

View full text Add to dashboard Cite

The discovery by Dodds, Golberg, Lawson, and Robinson [1938] of a new synthetic oestrogenic substance, diethylstilboestrol, with an oestrogenic potency resembling that of oestrone [Dodds, Lawson, and Noble, 1938; has stimulated investigations dealing with the further biological properties of this compound. The action of diethylstilboestrol proves to be similar in many respects to that of oestrone. This applies to its effect on the uterine mucosa [de Fremery and Geerling, 1939], the hypophysis [Noble, 1938], the male genital system [Gaarenstroom, 1939 b], the feathering of cocks and the comb of the capon M\l=u"\hlbock,1939], the sex of the chick embryo [Gaarenstroom, 1939 a], &c.The synthesis of diethylstilboestrol is comparatively cheap and therefore this compound arouses clinical interest. With regard to its clinical application it was necessary to have exact information about a possible toxic action, since Loeser [1939] and Cobet, Ratschow, and Stehner [1939] recently reported toxic effects following its use in several species of animals, which were not produced by corresponding amounts of oestrone. These effects consisted of vaginal and intestinal bleedings, degenerative changes in liver and kidneys, a disturbance of the general condition, &c. Further, the carcinogenic effect of diethylstilboestrol is claimed to be much greater than that of oestrone [Lacassagne, 1938]. notable disturbances arising from its clinical administration. There is some evidence, therefore, to show that diethylstilboestrol possesses a greater activity than oestrone in the production of certain toxic effects. In view of this fact we investigated the extent to which a well-known undesirable effect of oestrone, the growth inhibition following its admini¬ stration in large doses, is produced by diethylstilboestrol.

show abstract

“…Ever since the work of Evans and Long (6) and Freud et al (7), assay of growth hormone has been carried out by injecting the hormone into animals and measuring either the resulting weight gain or the increased thickness of skeletal epiphyses. These effects depend in part on intermediation by somatomedin C or insulin-like growth factor I (1,39).…”

mentioning

confidence: 99%

Activity of human growth hormone and related polypeptides on the adipose conversion of 3T3 cells.

Morikawa¹,

Green²,

Lewis³

1984

Mol. Cell. Biol.

View full text Add to dashboard Cite

show abstract

Observations on Growth (Chondrotrophic) Hormone and Localization of Its Point of Attack

Cited by 46 publications

References 0 publications

The histology and in vivo sulphate uptake of epiphyseal cartilage in protein-depleted rats

The histology and in vivo sulphate uptake of epiphyseal cartilage in protein-depleted rats

Disturbance of Growth by Diethylstilboestrol and Oestrone

Activity of human growth hormone and related polypeptides on the adipose conversion of 3T3 cells.

Contact Info

Product

Resources

About