Observations on phenomenological changes in <i>Klebsiella Pneumoniae</i> under fluidic stresses

Jain, Siddhant; Singh, Anmol; Tiwari, Nivedita; Naik, Aparna; Chatterjee, Ritika; Chakravortty, Dipshikha; Basu, Saptarshi

doi:10.1039/d3sm01521a

Cited by 1 publication

(2 citation statements)

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“…While this work provided insight into the genes responsive to flow, lingering questions remained about whether the regulation of f ro genes contributes to the viability and virulence of the cell. Jain et al 17 conducted experiments to investigate the effect of the flow shear rate on the viability, They employed micro-sized chambers of various shapes to modify flow rates and stress durations, discovering that elevated shear rates led to decreased population viability. The stressed bacterial population displayed elongated cell lengths.…”

Section: ■ Contact-free Dropletsmentioning

confidence: 99%

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Interfacial Stresses within Droplets and Channels Influence Bacterial Physiology: A Perspective

Jain,

Chakravortty,

Basu

2024

Langmuir

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Bacterial cells frequently experience fluid motion in their natural environments, like water bodies, aerosols, fomites, human capillaries, etc., a phenomenon that researchers have largely overlooked. Nevertheless, some reports have suggested that the interfacial stresses caused by fluid motion inside evaporating droplets or shear flows within capillaries may trigger physiological and morphological changes in the bacterial cells. Remarkably, the virulence of bacterial cells exhibits significant alterations in response to fluctuations in stress levels and external environmental factors. The dynamics of bacterial systems are analogous to colloidal systems but with the distinction that bacterial systems exhibit responsiveness, necessitating thorough exploration in dynamic environments. In this perspective, we discuss the important issue pertaining to bacterial survival, virulence, and disease transmission. Furthermore, we delineate a pathway and underscore emerging opportunities that demand exploration to unveil new avenues in the domains of bacterial pathogenicity, drug development, and strategies for disease mitigation.

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Section: ■ Contact-free Dropletsmentioning

confidence: 99%

“…The effect of shear stresses in the case of wall-bound flows has been studied in the context of bacterial trapping 15 and biofilm streamer formation. 16 Recent works by Jain et al 17 and Padron et al 18 take into account the effect of the dynamical flow field on bacterial physiology.…”

Section: ■ Introductionmentioning

confidence: 99%

Interfacial Stresses within Droplets and Channels Influence Bacterial Physiology: A Perspective

Jain,

Chakravortty,

Basu

2024

Langmuir

View full text Add to dashboard Cite

show abstract

Observations on phenomenological changes in Klebsiella Pneumoniae under fluidic stresses

Abstract: In the present work, experiments are conducted to understand the consequence of stresses generated by flowing fluid on the bacterial morphology and virulence in microfluidic channels. We consider Klebsiella pneumoniae...

Cited by 1 publication

References 76 publications

Interfacial Stresses within Droplets and Channels Influence Bacterial Physiology: A Perspective

Interfacial Stresses within Droplets and Channels Influence Bacterial Physiology: A Perspective

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