Observations on Some "Fast" Haemoglobins: K, J, N, and "Bart's"

A Further Abnormality of Foetal Haemoglobin

“…The present report is concerned with a new variant of foetal haemo globin detected during this survey by starch-gel electrophoresis at pH 6.8 (sample no. 689); at this pH the new variant moved anodically slightly faster than haemoglobin F, but definitely slower than the fast foetal components reported by Fessas and Papaspyrou (7) and by Acer and Lehmann (8).…”

Thalassemia

“…By the beginning of the 20th century, European clinicians had become aware of an anemia syndrome in infancy associated t of the spleen [8]. In the American literature the first clinical description of thalassemia is attributed to the Detroit pediatriciansThomas B. Cooley and Pearl Lee [9].…”

The Thalassemias and Related Disorders

“…Simpler methodology was developed that made it possible for routine laboratories the thalassemias and related disorders to analyze levels of hemoglobin A 2 and confirm the diagnosis of thalassemia (18). Other observations on the alterations of hemoglobin patterns in patients with thalassemia led to the discovery of HbH (β 4 ) (19) and Hb Barts (γ 4 ) (20), which later became established markers of alpha-thalassemia.…”