Observations on the Accumulation of Mononuclear Cells and the Activities of Reticulum Cells in Bone Marrow of Guinea-Pigs Recovering from Whole Body Gamma Irradiation

Quantitative Study of the Hemopoietic Recovery after a Sublethal X-Irradiation in the Mouse

“…What is the significance of this rapidly changing X-cells population? It is likely that these cells are the same as the lymphoid cells called 'transitional cells' by other authors which assume a relation between the transitional cells and other marrow elements [3,4,5,6,10]. The present results are in contradiction with this assumption.…”

“…Particular attention has been drawn on the accumulation of small mononucleated cells in the bone-marrow of animals recovering from an irradiation [3,4]. These cells, morpho logically similar to the lymphocyte from which they can nevertheless be distinguished by some cytological characters, have received the name o f'transitional cells' [5,6].…”

An Investigation of Lymphocyte Production in Guinea-Pig Bone Marrow

“…It must be stressed that this paucity does not exist in the irradiated guineapig. Many lymphocytopoietic cells are easily recognisable in mar XXXIII/1965 366 row regenerating after irradiation (7,8). The present experiments do not establish whether the lymphocyte precursors originate in lymphoid tissues and enter the blood stream to reach the marrow where they divide to form small lymphocytes, or whether they originate in foetal marrow and persist in the marrow post-natally.…”

“…Previous studies of bone marrow recovering from irradiation (7,8) have shown that at a certain stage during the recovery many of its dividing cells (%-]/2 of all telophases) appear to be forming small or medium-sized lymphocytes. Experiments were therefore planned in which the problem of lymphocyte production in guineapig bone marrow has been further investigated.…”

Cytokinetics of Bone Marrow Stroma Cells after Stimulation by Partial Depletion of the Medullary Cavity

“…It was expected that by the method used new information could be obtained about an adequate stimulus for proliferation of stroma cells which under normal steady state conditions are cytokinetically at rest [4,11,14]. As already mentioned, 2 particular questions were of interest in our investigations: (1) Is it possible to trigger resting stroma cells of the bone marrow to proliferate by partial depletion?…”