Observations on the Assessment of Cardiac Hypertrophy Utilizing a Chamber Partition Technique

Abstract

Three hundred fifty-four adult human hearts were dissected utilizing a technique similar to those previously described by Müller 1 and Lewis. 2 A classification was synthesized on the basis of anatomic characteristics of 100 normal hearts. Presumptive evidence of either left or right ventricular overload, provided by clinical and autopsy observation, served as essential corollary data in establishing normal limits. The existence of hypertrophy was readily recognized in hearts in which one or both ventricles increased in mass sufficiently to surpass the defined upper limit. Isolated ventricular hypertrophy of mild degree was recognized as a consequence of an abnormal LV+S/RV ratio in 58 hearts in which ventricular weights were within the normal range. Factors which would be expected to result in left or right ventricular overload were demonstrable in 42 of these cases. Atrial hypertrophy correlated well with hypertrophy of the corresponding ventricle and served as an invaluable aid in recognition of mild degrees of combined ventricular hypertrophy. This classification constitutes the basis for a subsequent correlative electrocardiographic study.

Electrocardiogram for the Diagnosis of Right Ventricular Hypertrophy and Dilation in Idiopathic Pulmonary Arterial Hypertension

“…An additional limitation of these postmortem studies was a lack of a clear anatomic definition of RVH. 20 These limitations were overcome in our present study in which the ECG and RV mass were measured on the same day. Additionally, in order to assess the accuracy of different ECG criteria in the diagnosis of RVH or dilation we used clearly defined cut-off values based on CMR studies made in healthy subjects.…”

Histological Characterization of Dilated Cardiomyopathy in the Juvenile Toy Manchester Terrier

“…A moderately to markedly decreased RV/LV ratio was identified in 2 of 6 TMTs; this could indicate thinning of the RV free wall or thickening of the LV. However, ventricular wall thickness is modified by factors such as rigor mortis and dilation, such that simultaneous ventricular hypertrophy and dilation could result in an apparently ''normal'' wall thickness 5 and mask hypertrophy. 48 The variation in gross morphology in these dogs could reflect diversity in cardiac alterations or the subjectivity of visual interpretation by different veterinary pathologists.…”

“…Postmortem reports were available for 14 TMTs that were confirmed to be affected based on microscopic lesions identified by microscopic examination of submitted slides or paraffin-embedded tissues (TMT CM Nos. [1][2][3][4][5][6][7][8][9][10][11][12] or based on microscopic cardiac lesions described in the submitted postmortem reports (TMT CM Nos. 13 and 14).…”

“…Five dogs (TMT CM Nos. 1,5,8,9, and 14 with ratios of 1.07, 1.44, 1.07, 1.08, and 1.00, respectively) had increased HW/BW ratios (normal range is 0.58%-0.94% of total body weight), 48 and the remaining dog had a decreased ratio (TMT CM No. 12 with a ratio of 0.56).…”

Exercise-induced arterial hypertension - an independent factor for hypertrophy and a ticking clock for cardiac fatigue or atrial fibrillation in athletes?

“…According to the values reported by Devereux et al 40 and Bove et al 41 , we divided the triathletes in two groups: group 1 (LVM >220g) and group 2 (LVM <220g) to assess the possible reasons for left ventricular hypertrophy. The significant differences between the two groups are shown in Table 1 and The probability of dependent factors for LV-hypertrophy was calculated by odds ratios (Table 5).…”