Observations on the BT PABA/14C-PABA tubeless test of pancreatic function

Braganza, Joan M.; Kay, G; Tetlow, Vincent A.; Herman, K

doi:10.1016/0009-8981(83)90308-x

Cited by 32 publications

(3 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consequently, our figure for specific ity may be unreliable, but we feel it provides some guidance, especially since our figure (89%) agrees closely with that of Braganza et al [15] (86%). Although the results indicate that the calculation of the PEI is still rela tively imprecise (sensitivity 83%, specificity 89%), these represent acceptable figures for a single non-invasive test of pancreatic func tion.…”

Section: Discussionsupporting

confidence: 80%

“…Although the results indicate that the calculation of the PEI is still rela tively imprecise (sensitivity 83%, specificity 89%), these represent acceptable figures for a single non-invasive test of pancreatic func tion. Using the PABA test alone, our prelim inary data would indicate a predictive value for a positive result of 7%, as compared to the quoted figure of 6.5% [15]. The predic tive value of a positive pancreolauryl test is 4% using quoted results in the literature [1][2][3][4], All these figures assume a population prevalence of 1%.…”

Section: Discussionmentioning

confidence: 50%

See 1 more Smart Citation

An Evaluation of the One-Day NBT-PABA/<sup>14</sup>C-PABA in the Assessment of Pancreatic Exocrine Insufficiency

et al. 1984

View full text Add to dashboard Cite

The one-day NBT-PABA/¹⁴C-PABA has been performed on 58 consecutive subjects with suspected or established pancreatic disease. 23 of these were normal subjects, 12 were subsequently shown to have other gastrointestinal disease and 23 had proven pancreatic disease. A PABA excretion index (PEI) has been calculated and, using our lower limit of normality (0.61), the test has shown an overall sensitivity of 83 % and specificity of 89 %. False positives were a particular problem in the other gastrointestinal disease group (25%). There was a close correlation between PEI and Lundh mean tryptic activity (r = 0.89). These results indicate that this test is a satisfactory screening test for pancreatic exocrine disease and is easier to perform with less likelihood of error than many other non-invasive tests of pancreatic function.

show abstract

Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 50%

An Evaluation of the One-Day NBT-PABA/<sup>14</sup>C-PABA in the Assessment of Pancreatic Exocrine Insufficiency

et al. 1984

View full text Add to dashboard Cite

show abstract

“…Interference with the spectrophotometric assay of PABA by drugs including sulphonamides, diuretics, paracetemol, chloramphenicol, and food such as prunes and cranberries causes a high test failure rate. 12 False positive tests may occur in the newborn, when there is immature renal function or when urine collection is incomplete. False negative results have been described in Shwachman's syndrome,'3 possibly due to hydrolysis of NBT-PABA by mucosal paba-peptide hydrolase.…”

Section: Bentiromide Testmentioning

confidence: 99%