Observations on the Character of Mercurial Diuresis

Dale, Rick; Sanderson, P. H.

doi:10.1111/j.1476-5381.1954.tb00843.x

Cited by 7 publications

(4 citation statements)

References 18 publications

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“…This is supported by the action of ethacrynic acid and mersalyl on potassium excretion in human subjects. Dale and Sanderson (1954) demonstrated a potassium conserving effect of mersalyl in normal subjects which was abolished if hyperaldosteronism was induced. Ethacrynic acid consistently increases potassium excretion in both normal subjects and oedematous patients (Dollery, Parry & Young, 1964).…”

Section: Discussionmentioning

confidence: 95%

A Comparison of the Effects of Ethacrynic Acid and a Mercurial Diuretic (Mersalyl) on Sodium Transport Across the Isolated Frog Skin

Baba

Smith

Townshend

1966

British Journal of Pharmacology and Chemotherapy

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Section: Discussionmentioning

confidence: 95%

A Comparison of the Effects of Ethacrynic Acid and a Mercurial Diuretic (Mersalyl) on Sodium Transport Across the Isolated Frog Skin

Baba

Smith

Townshend

1966

British Journal of Pharmacology and Chemotherapy

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“…Although the acute administration of such diuretics as organomercurials, chlorothiazide, furosemide and ethacrynic acid induces a transient increase in urate excretion [11,18], it is well known that when given on a chronic basis, acetazolamide, chlorothiazide, furose mide and ethacrynic acid reduce urate excre tion and induce hyperuricemia [11,19]. Such an effect has been attributed to contraction of the extracellular volume [20,21] leading to im- paired tubular secretion or increased reab sorption of urate [21].…”

Section: Discussionmentioning

confidence: 99%

Metabolie Effects in Man of Tienilic Acid, a New Diuretic with Uricosuric Properties

Lemieux¹,

Gougoux²,

Vinay³

et al. 1978

Nephron

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Acute and chronic studies were performed on 6 bealthy human volunteers. Four subjects took a Single oral dose of tienilic acid 1,000 mg. A week later, the same subjects took pyrazinamide (PZA) orally 3 g 90 min prior to the ingestion of the same dose of tienilic acid. Following tienilic acid alone, a marked uricosuric effect lasting at least 8 h was noted, the ratio of urate clearance over endogenous Creatinine clearance (Cur/Ccr) reaching 0.55. At the same time, plasma urate feil from 6.8 to 2.7 mg%. After PZA, the uricosuric response to tienilic acid was only slightly depressed during the first 4 h. However, the blunting effect became more important during the next 20 h. During the chronic studies tienilic acid (250–500 mg/day) was administered during 7 days to 6 subjects maintained on a constant diet. In these studies Cur/Ccr rose from 0.11 to 0.25 while plasma urate decreased from 6.0 to 3.0 mg%. Hydrochlorothiazide administered in equivalent dosage (50–100 mg/day) induced a fall in Cur/Ccr from 0.09 to 0.05. This was accompanied by a significant rise in plasma urate from 6.3 to 7.8 mg%. Cumulative increase in urinary sodium excretion after 7 days was slightly higher with hydrochlorothiazide than with tienilic acid. Total body loss averaged 1.9 kg with tienilic acid and 2.2 kg with hydrochlorothiazide. However, in contrast to hydrochlorothiazide, the cumulative increase in potas-sium excretion was much greater with tienilic acid and serum potassium feil from 4.0 to 3.4 mEq/1. At the same time net urinary hydrogen ion excretion rose markedly and was accompanied by the development of moderate metabolic alkalosis serum bicarbonate rising from 26.5 to 34.2 mEq/1. Tienilic acid had a definite hypocalciuric effect. However, the latter was less important than that induced with hydrochlorothiazide. Tienilic acid, a new diuretic, appears to be a potent uricosuric agent in normal man when administered on an acute or a chronic basis. In spite of a moderate natriuretic effect, it exerts a marked action on both potassium and net acid excretion with resulting hypokalemia and metabolic alkalosis.

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“…However, in the presence of excess aldosterone this depressant effect may be partially overcome. Normal subjects taking a low-sodiurn diet show an increased potassium excretion when given mersalyl (Dale and Sanderson, 1954). Similarly in clinical conditions associated with increased aldosterone secretion potassium depletion may complicate prolonged treatment with mersalyl.…”

Section: Metabolic Disturbancesmentioning

confidence: 99%

Diuretics

Wilson¹

1963

BMJ

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Observations on the Character of Mercurial Diuresis

Cited by 7 publications

References 18 publications

A Comparison of the Effects of Ethacrynic Acid and a Mercurial Diuretic (Mersalyl) on Sodium Transport Across the Isolated Frog Skin

A Comparison of the Effects of Ethacrynic Acid and a Mercurial Diuretic (Mersalyl) on Sodium Transport Across the Isolated Frog Skin

Metabolie Effects in Man of Tienilic Acid, a New Diuretic with Uricosuric Properties

Diuretics

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