Observations on the Development of Dysplasia

Heinzl, SIGFRlED; Szalmay, G; Jochum, L.; Roemer, V. M.

doi:10.1097/00006254-198307000-00022

Cited by 3 publications

(3 citation statements)

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“…1 Many prospective follow-up studies of low-grade SIL have found rates of regression, progression, and persistence including the report by Nasiell et al 11 According to those studies, 44% regress spontaneously, about 46% persist, and approximately *15% of low-grade SIL lesions have the potential for progressing to high-grade SIL, if left untreated. 2,[11][12][13][14][15][16] Thus, it is very important to distinguish those women with low grade-SILs that would regress from those with such lesions that would persist or progress. In our study for low-grade SIL cases, the L1 capsid antigen-positive rate was relatively higher in the low-risk group than in the high-risk group.…”

Section: Discussionmentioning

confidence: 99%

Expression of HPV L1 capsid protein in cervical specimens with HPV infection

Lee¹,

Lee²,

Jung³

et al. 2008

Diagnostic Cytopathology

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We tried to investigate the expression rate of human papillomavirus (HPV) L1 capsid protein in uterine cervical specimens and correlate it with the grade of dysplasia, HPV genotype and age of the patients. Among uterine cervical specimens proved to have HPV by DNA genotyping test, eighty cytology-biopsy matched cases and 22 unmatched cytology specimens were selected. Immunostaining for L1 capsid protein was performed on both cervical smears and tissue sections. The L1 capsid protein was expressed mainly in the nuclei, but occasionally in the cytoplasm of cells located in the superficial layer of squamous epithelium. The immunostaining for L1 capsid protein showed positive reaction in 47 cases (46.1%) of cervical smears and in 10 cases (12.5%) of tissue sections (P = 0.001). Cytologic diagnosis revealed a higher expression rate in LSILs (25/33; 75.8%) than in HSILs and cervical cancers (8/20; 40.0% and 2/5; 40%, respectively) (P = 0.006). In LSILs, cases with low-risk type HPV showed a higher L1 capsid expression rate than those with the high-risk type HPV (88.9% vs. 70.8%). The L1 capsid expression rate decreased in the over-40-year-old age group compared to the younger age (49.2% vs. 50.8%). Cytology smears were superior to tissue sections for the detection of L1 capsid protein expression. LSILs and HPV low-risk group showed higher L1 capsid expression rate than HSILs and HPV high-risk group, which suggests that L1 capsid expression might be related to a favorable disease biology.

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Section: Discussionmentioning

confidence: 99%

Expression of HPV L1 capsid protein in cervical specimens with HPV infection

Lee¹,

Lee²,

Jung³

et al. 2008

Diagnostic Cytopathology

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“…The data also revealed an apparent decrease of Ag-NORs in severe dysplasia cases when compared with controls. The trend of decrease in the frequency of Ag-NORs in cancer and severe dysplasia cases is interesting, because the progression rate of this severe grade of precancerous lesion to cancer was reported to be significantly more in comparison with milder forms of precancerous groups [20][21][22][23].…”

Section: Discussionmentioning

confidence: 99%

Nucleolar organizer regions in patients with precancerous and cancerous lesions of the uterine cervix

Murty

Mitra

Sharma

et al. 1985

Cancer Genetics and Cytogenetics

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Nucleolar organizer regions (Ag-NORs) were studied in patients with cervical precancerous and cancerous lesions along with controls. The data revealed a statistically significant decrease of Ag-NORs in cancer patients, as well as in women with severe precancerous lesions as compared with controls. A similar decrease in the amount of Ag-staining was also observed in both cancer and severe dysplasia cases. The study suggests a possible relationship of Ag-NOR activity to malignancy.

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“…On peut considérer en moyenne que 10 à 15 % des CIN 1 non traitées vont évoluer spontanément vers une CIN 2 ou 3. Cinquante à soixante pour cent des CIN 1 régressent spontanément et 35 % vont persister [11][12][13][14][15]. Le risque de progression d'une CIN 1 vers une CIN 3, ou un cancer invasif, est estimé à 1 % par an, tandis que le risque de progression d'une CIN 2 est de 16 % à deux ans et de 25 % à cinq ans [16].…”

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Histoire naturelle des lésions précurseurs du cancer du col utérin

Tranbaloc

2008

Gynécologie Obstétrique & Fertilité

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Observations on the Development of Dysplasia

Cited by 3 publications

References 0 publications

Expression of HPV L1 capsid protein in cervical specimens with HPV infection

Expression of HPV L1 capsid protein in cervical specimens with HPV infection

Nucleolar organizer regions in patients with precancerous and cancerous lesions of the uterine cervix

Histoire naturelle des lésions précurseurs du cancer du col utérin

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