Observations on the Developmental Patterns and the Consequences of Pancreatic Exocrine Adenocarcinoma

Mao, Chuanyan; Domenico, Don R.; Kim, Kitai; Hanson, Daniel J.; Howard, John M.

doi:10.1001/archsurg.1995.01430020015001

Cited by 97 publications

(60 citation statements)

References 35 publications

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“…Pancreatic cancer usually metastized to liver and peritoneal cavity and less common to lung, bone and brain [5,8] and less frequently to ovary, ureter and umbilical region, bony metastasis to appendicular skeleton is common but metastasis to scapular region is rare. There are few case reports in which cancer like lung, esophagus, colon, germ cell tumor develop metastasis to scapula [12][13][14][15].To the best of our knowledge there is only one abstract published in literature which reported isolated right scapula metastasis from ampullaryadenocarcinoma [16].Patients presented with metastasis, usually have one or more site of disease most common being the liver followed by peritoneum and lungs [17][18][19]. In present study, patient has liver as well as skeletal metastasis including scapular involvement.…”

Section: Discussionmentioning

confidence: 99%

Extensive periampullary carcinoma with scapula metastasis: a case report

Sharma¹,

Singh²,

Kakkar³

et al. 2016

APJHS

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Pancreatic carcinoma is a devastating carcinoma and is currently the fourth leading cause of cancer mortality in the United States. Periampullary cancer consists of pancreatic cancer, carcinoma of ampulla of vater, distal common bile duct and duodenum. Most common sites of metastasis are liver and peritoneum and other less common sites are lung, brain, kidney and bone in carcinoma pancreas .The prevalence of bone metastasis has been estimated between 5% to 20%.Here we are reporting a case of extensive periampullary carcinoma with scapular metastasis, which is a rare site of metastasis.

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Section: Discussionmentioning

confidence: 99%

Extensive periampullary carcinoma with scapula metastasis: a case report

Sharma¹,

Singh²,

Kakkar³

et al. 2016

APJHS

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“…Peritoneal spread is common in pancreatic adenocarcinoma occurring in up to 55% of patients in autopsy series [37][38][39]. Due to its unique location in the retroperitoneum, pancreatic adenocarcinoma spread to the peritoneum can vary based on the location of the primary tumor.…”

Section: Staging Nodal Diseasementioning

confidence: 99%

Imaging in Staging and Management of Pancreatic Ductal Adenocarcinoma

Vikram

Balachandran

2010

Indian J Surg Oncol

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Pancreatic cancer is a relatively common malignancy of the gastrointestinal tract for which complete surgical excision remains the only curative option. Being infiltrative in nature and bearing a complex anatomical relationship with various organs, peritoneal ligaments and vascular structures, accurate anatomical staging is key in treatment of these patients. In this article, we will discuss and provide a brief overview of anatomy and use of imaging in staging pancreatic cancer.

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“…Liver metastases is one of the most common forms of hematogenous spread in patients with various malignancies (1,2), and the development of effective treatment modalities for liver metastases using convenient animal models is highly desirable. Because the liver is the largest solid organ, a reliable animal model of liver tumors is also valuable for in vivo evaluation of various therapeutic agents.…”

Section: Introductionmentioning

confidence: 99%

Consistent Liver Metastases in a Rat Model by Portal Injection of Microencapsulated Cancer Cells

Enomoto¹,

Oda²,

Aoyagi³

et al. 2006

Cancer Research

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Consistent liver metastases in animal models is generally observed only with certain cancer cell lines. With the aim of improving on existing animal models of liver metastases, we hypothesized that cancer cells encased in 300 Mm microcapsules, mimicking micrometastatic foci, might be effective seeds of liver metastases. A total of 3,000 microcapsules, containing 700 to 1,500 viable cells/capsule in logarithmic growth phase of three human pancreatic cancer cell lines (SUIT-2, AsPC-1, and BxPC-3), were transplanted in nude rats by portal injection. The rate of liver metastases was 100% (12 of 12), 100% (6 of 6), and 83% (5 of 6) for SUIT-2, AsPC-1, and BxPC-3 microcapsules, respectively. In contrast, the administration of an identical number of single cancer cells (2.1-4.5 Â 10 6 ) did not lead to liver metastases. Metastases was strictly limited to the liver, was quite stable, and could be proportionately tailored by varying the number of cancer microcapsules administered. Microscopic observation showed that two-thirds of the cancer microcapsules were lodged in the peripheral small (20-50 Mm) portal veins, although onethird of the cancer microcapsules were trapped in the central wide (200-400 Mm) portal vein. Capsules began to burst at day 3, with recognizable metastases produced at day 7, resulting in overt metastases production at days 28 to 42. The present cancer microcapsule method may be useful for obtaining liver metastases in animal models, especially for cell lines that will not form liver metastases with conventional single cell injection methods and/or for experiments requiring the consistent formation of liver metastases. (Cancer Res 2006; 66(23): 11131-9)

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Observations on the Developmental Patterns and the Consequences of Pancreatic Exocrine Adenocarcinoma

Cited by 97 publications

References 35 publications

Extensive periampullary carcinoma with scapula metastasis: a case report

Extensive periampullary carcinoma with scapula metastasis: a case report

Imaging in Staging and Management of Pancreatic Ductal Adenocarcinoma

Consistent Liver Metastases in a Rat Model by Portal Injection of Microencapsulated Cancer Cells

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