Observations on the Effect of Testosterone and Hydrocortisone on Erythropoiesis*

Glader, Bertil; Rambach, Walter A.; Alt, Howard L.

doi:10.1111/j.1749-6632.1968.tb15172.x

Cited by 9 publications

(4 citation statements)

References 7 publications

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“…Gluco corticoid administration results in an increased erythropoiesis in hypophysectomized [7] starved and polycythemic rats and mice [2,14], On the other hand, large doses of hydrocortisone appear to depress erythropoiesis [17]. Recently, a direct, 'erythropoietin-like' effect of dexamethasone on bone marrow erythroid cells has been suggested [1,3].…”

mentioning

confidence: 99%

Effects of Dexamethasone on Bone Marrow Erythropoiesis

Malgor¹,

Torales²,

Klainer³

et al. 1974

Horm Res

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A stimulatory effect on bone marrow erythroid cells was observed in normal rats treated with dexamethasone. The erythropoietic effects of dexamethasone were completely abolished in rats with bilateral nephrectomy. In addition, simultaneous administration of corticosteroid with antibodies against erythropoietin in normal rats also resulted in a complete inhibition of the stimulatory action of dexamethasone on the bone marrow erythroid compartment. These results suggest that dexamethasone stimulates erythropoiesis indirectly, through a previous stimulation of kidney erythropoietin production.

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confidence: 99%

Effects of Dexamethasone on Bone Marrow Erythropoiesis

Malgor¹,

Torales²,

Klainer³

et al. 1974

Horm Res

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“…The mechanisms for a similar proportionate rise in the haemoglobin concentration are, in contrast, poorly delineated. Changes in plasma volume may play a part (Kleeman et al, 1960;Glader, Rambach and Alt, 1968) as may changes in the red cell mass (Glader et al, 1968;Peschle et al, 1974). Such mechanisms need more complete investigation since the precipitous fall in the haemoglobin concentration after steroid withdrawal in this patient implies a significant plasma volume effect.…”

Section: Discussionmentioning

confidence: 99%

Leuco-erythroblastosis following withdrawal from glucocorticoid therapy

Trenchard

Wells

Jarriwalla

1977

Postgraduate Medical Journal

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Summary Leuco-erythroblastosis has many known associations (Burkett, Cox and Fields, 1965; Weick, Hagedorn and Linman, 1974; Retief, 1964), but the only ones related to drug therapy are the well established response to haematinics (Burkett et al., 1965) and one possible case following anti-epileptic therapy (Retief, 1964). The case described below is of leuco-erythroblastosis following steroid withdrawal in a young man with primary polymyositis.

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“…In spite of some controversial data [20] on the long-term effect, there is no doubt on the satisfactory results of this treatment in the majority of the patients. A mechanism of action of an drogens seems to be an increased secretion of erythropoietin, but other mechanisms of action probably play a role in stimulating erythropoiesis [7,9,10]. The side effects of this therapy, liver toxicity and virilization in females, justify temporary withdrawal of treatment, followed by a trial with another androgen, only in case of icterus.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, it has recently been shown that glucocorticoids inhibit erythropoiesis in normal rats [7,10]. Therefore, the use of glucocorticoids in the therapy of aplastic anemia seems justified only in the initial phase, when in a severely thrombocyto penic patient, the coagulant action of glucocorticoids [14,21] might be useful, or in emergency.…”

Section: Discussionmentioning

confidence: 99%

Aplastic Anemia: Some Clinical and Laboratory Aspects and an Evaluation of the Androgen-Glucocorticoid Treatment

Corneo¹,

Cortellaro²,

Maiolo³

1971

Acta Haematol

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Some clinical aspects in 18 patients affected by aplastic anemia are considered. Liver involvement might be due to serum hepatitis, drug toxicity and possibly to the same etiologic factors causing aplastic anemia. In some patients a decreased glucose tolerance has been found. Serum immunoglobulin levels were normal in the majority of the patients. In one patient there was hypogammaglobulinemia and in a few patients hypergammaglobulinemia in the absence of liver diseases and infections. Concerning therapy, androgens appear to be beneficial, while glucocorticoids were unuseful and in several occasions dangerous.

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Observations on the Effect of Testosterone and Hydrocortisone on Erythropoiesis*

Cited by 9 publications

References 7 publications

Effects of Dexamethasone on Bone Marrow Erythropoiesis

Effects of Dexamethasone on Bone Marrow Erythropoiesis

Leuco-erythroblastosis following withdrawal from glucocorticoid therapy

Aplastic Anemia: Some Clinical and Laboratory Aspects and an Evaluation of the Androgen-Glucocorticoid Treatment

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