Objective: To systematically evaluate the clinical efficacy of acupuncture for general anxiety disorders by using evidence-based medicine. Methods: Online databases such as CNKI, VIP, Wanfang and PubMed were searched by computer, and references of randomized controlled trials (RCTS) of acupuncture therapy for generalized anxiety disorder (GAD) were screened out. The retrieval time was from the establishment of the database to December 2020. The RevMan 5.3 software was used for Meta analysis of Hamilton Anxiety scale (HAMA), Self-rating Anxiety Scale (SAS), total clinical effectiveness and adverse reactions in included randomized controlled trial (RCTS) literature. Results: A total of 19 RCTS were included in this meta-analysis, involving 1,493 patients, including 772 in the acupuncture group and 721 in the western medicine group. The Meta-analysis results showed that the effective rate of acupuncture treatment of GAD patients was better than that of western medicine group [RR=1.06, 95%CI (1.02, 1.10), P=0.003], and the adverse reactions were significantly lower than that of western medicine group [RR=0.25, 95%CI (0.11, 0.53), P=0.0004]. However, there was no significant difference in HAMA [MD=-0.71, 95%CI (-2.25, 0.83), P=0.37] and SAS [MD=-0.64, 95%Cl (-2.52, 1.24), P=0.51] of GAD patients after treatment in outcome indicators. Conclusion: Acupuncture is better than western medicine in treating generalized anxiety disorder. However, the evidence of efficacy is limited and more high-quality, big-data, multicenter RCT literature is needed for further study.