1968
DOI: 10.1055/s-0038-1651187
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Observations on the Lysis of Artificial Thrombi by Urokinase

Abstract: Summary1. The extent of lysis of artificial thrombi by urokinase is dependent on their fibrin content and on the plasminogen concentration of the plasma from which they are made.2. The lysis of thrombi in the presence of plasma increases with increasing concentrations of urokinase, but very high urokinase concentrations are inhibitory to thrombolysis.3. It is postulated that incomplete thrombolysis is due to insufficient plasmin formation within the thrombus, but that plasminogen-containing plasma can diffuse … Show more

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“…Artificial thrombi with a histological structure similar to that of in vivo mixed thrombi have been used recently to study in vitro thrombolysis a, b, McNicol et al 1965, Ogston et al 1968, Lawson et al 1973.…”
Section: Introductionmentioning
confidence: 99%
“…Artificial thrombi with a histological structure similar to that of in vivo mixed thrombi have been used recently to study in vitro thrombolysis a, b, McNicol et al 1965, Ogston et al 1968, Lawson et al 1973.…”
Section: Introductionmentioning
confidence: 99%