Observations on the new growth of lymphatic vessels as seen in transparent chambers introduced into the rabbit's ear

Clark, Eliot R.; Clark, Eleanor Linton

doi:10.1002/aja.1000510104

Cited by 107 publications

(46 citation statements)

References 16 publications

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“…With the advent of new markers for and reagents that can be used to manipulate lymphatic vessels, the findings of many classical studies are beginning to be understood on a molecular level (21,27,28). Earlier studies showed that lymphatic vessels proliferate in wounds and inflammation of skin (3,16,29) and cornea (30). Some experiments also suggested that lymphangiogenesis occurs more slowly than angiogenesis (15,16,31).…”

Section: Discussionmentioning

confidence: 39%

Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation

Bałuk¹,

Tammela²,

Ator³

et al. 2005

J. Clin. Invest.

516

503

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Edema occurs in asthma and other inflammatory diseases when the rate of plasma leakage from blood vessels exceeds the drainage through lymphatic vessels and other routes. It is unclear to what extent lymphatic vessels grow to compensate for increased leakage during inflammation and what drives the lymphangiogenesis that does occur. We addressed these issues in mouse models of (a) chronic respiratory tract infection with Mycoplasma pulmonis and (b) adenoviral transduction of airway epithelium with VEGF family growth factors. Blood vessel remodeling and lymphangiogenesis were both robust in infected airways. Inhibition of VEGFR-3 signaling completely prevented the growth of lymphatic vessels but not blood vessels. Lack of lymphatic growth exaggerated mucosal edema and reduced the hypertrophy of draining lymph nodes.

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Section: Discussionmentioning

confidence: 39%

Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation

Bałuk¹,

Tammela²,

Ator³

et al. 2005

J. Clin. Invest.

516

503

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show abstract

“…In full-thickness skin wounds, ingrowth of new blood vessels (angiogenesis) into the newly formed granulation tissue largely dominates the delayed and comparatively less pronounced formation of new lymphatic vessels (Paavonen et al 2000), which are predominantly located surrounding the blood vessel-rich granulation tissue. Lymphangiogenesis in the adult occurs by outgrowth from preexisting lymphatics (Clark and Clark 1932;Paavonen et al 2000); it remains to be established whether lymphangiogenesis during tissue repair also involves the incorporation of progenitor cell populations, as in blood vessel angiogenesis (Rafii 2000), or the budding of lymphatic precursors from preexisting veins, similar to lymphatic development during embryogenesis. The recent discovery of specific lymphatic markers will greatly facilitate studies to address this issue in more detail.…”

Section: Lymphatic Regenerationmentioning

confidence: 46%

The rediscovery of the lymphatic system: old and new insights into the development and biological function of the lymphatic vasculature

Oliver¹,

2002

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“…[27][28][29] In observing the CD31 staining patterns, it can be seen that the epithelialization and vascularization of the CDE occurred more quickly than lymphatic development (Figures 3b and 3f). The entire CDE was completely vascularized (CD31 ϩ /FITC-dextran Ϫ ) by day 10 after the procedure, although organization and trimming continued through day 60 (Figures 3f through 3h).…”

Section: Observation Of Lecs Versus Becsmentioning

confidence: 48%

Interstitial Flow as a Guide for Lymphangiogenesis

Boardman

Swartz

2003

Circulation Research

267

263

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Abstract-The lymphatic system is important in tissue fluid balance regulation, immune cell trafficking, edema, and cancer metastasis, yet very little is known about the sequence of events that initiate and coordinate lymphangiogenesis. Here, we characterize the process of lymphatic regeneration by uniquely correlating interstitial fluid flow and lymphatic endothelial cell migration with lymphatic function. A new model of skin regeneration using a collagen implant in a mouse tail has been developed, and it shows that (1) interstitial fluid channels form before lymphatic endothelial cell organization and (2) lymphatic cell migration, vascular endothelial growth factor-C expression, and lymphatic capillary network organization are initiated primarily in the direction of lymph flow. These data suggest that interstitial fluid channeling precedes and may even direct lymphangiogenesis (in contrast to blood angiogenesis, in which fluid flow proceeds only after the vessel develops); thus, a novel and robust model is introduced for correlating molecular events with functionality in lymphangiogenesis.

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Observations on the new growth of lymphatic vessels as seen in transparent chambers introduced into the rabbit's ear

Cited by 107 publications

References 16 publications

Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation

Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation

The rediscovery of the lymphatic system: old and new insights into the development and biological function of the lymphatic vasculature

Interstitial Flow as a Guide for Lymphangiogenesis

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