2008
DOI: 10.1152/japplphysiol.01260.2007
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Observations on the physiological interactions between obesity and asthma

Abstract: To explore whether asthma and obesity share overlapping pathogenic features, we examined the impact of each alone, and in combination, on multiple aspects of lung function. We reasoned that if they influenced the lungs through similar mechanisms, the individual physiological manifestations in the comorbid state should interact in a complex fashion. If not, then the abnormalities should simply add. We measured specific conductance, spirometry, lung volumes, and airway responsiveness to adrenergic and cholinergi… Show more

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Cited by 64 publications
(62 citation statements)
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“…In an earlier report, BMI was negatively correlated with the presence of AHR confirmed by MBPT [11], and others have reported that obesity is a risk factor for asthma and wheezing, but not for AHR [2,8,9,10,11,20,21]. However, many studies have shown a link between obesity and increases in both AHR and the prevalence of asthma in the general population [4,5,6,7].…”
Section: Discussionmentioning
confidence: 90%
See 1 more Smart Citation
“…In an earlier report, BMI was negatively correlated with the presence of AHR confirmed by MBPT [11], and others have reported that obesity is a risk factor for asthma and wheezing, but not for AHR [2,8,9,10,11,20,21]. However, many studies have shown a link between obesity and increases in both AHR and the prevalence of asthma in the general population [4,5,6,7].…”
Section: Discussionmentioning
confidence: 90%
“…Asthma is an airway disease characterized by chronic airway inflammation and airway hyperresponsiveness (AHR), but the evidence regarding a relationship between obesity and AHR has been inconsistent [5]. Some studies have reported that obesity increased AHR and that weight gain was positively related to the prevalence of AHR in general populations [4,5,6,7]; in contrast, other studies have shown no relationship, or even a negative association, between obesity and the presence of AHR in asthma patients [2,8,9,10,11]. Furthermore, there is evidence indicating that the chronic inflammation associated with obesity lessens Th2 inflammation [12,13,14], which is closely related to AHR in asthma.…”
Section: Introductionmentioning
confidence: 99%
“…BA and obesity are multifactorial diseases, which are influenced by both genetic factors and environmental factors [6]. It is assumed that the common genetic factors of these two diseases can partly explain the data of epidemiological investigations, which confirm a close association between BA and obesity.…”
Section: Introductionmentioning
confidence: 99%
“…Thus, BA and obesity are associated with the genes, which encode ȕ-adrenergic receptor (locus 5q, ADRB2 gene), insulin-like growth factor (locus 12q, IGF1 gene), IL-1Į (locus 12q, IL-1Į gene), leukotriene A4 hydroxylase (locus 12q, LTA4H gene), GR (locus 5q, NR3C1 gene), signal transducers and activators of transcription (locus 12q), TNF (locus 6p, TNF gene), uncou-pling protein (locus 11q13, gene UCP2 and 3), etc. [6].…”
Section: Introductionmentioning
confidence: 99%
“…(15) The combination of obesity and airflow obstruction can result in increased RV, without proportional increases in TLC, due to lower chest wall compliance, thereby reducing FVC and FEV 1 in a proportional manner. (22) In obese individuals, reduced FVC should not to be ascribed to excessive weight, unless complementary tests of restriction than does a greater reduction in FEV 1 %.…”
Section: Discussionmentioning
confidence: 99%