Observations on the Relations between Immunoconglutinins and Rheumatoid Factor

Complement metabolism in rheumatoid arthritis. I. Longitudinal studies.

“…More direct evidence of complement involvement in rheumatoid arthritis is the presence of IgG-BIC complexes in synovial fluid (Vaughan, Barnett, Sobel, and Jacox, 1968) and synovial cells (Hurd, LoSpalluto, andZiff, 1969, 1970). Increased complement consumption has been demonstrated by turnover studies of C3 component using radiolabelled C3 (Weinstein, Peters, Brown, and Bluestone, 1972) and is associated with raised immunoconglutinin levels (Marks and Coombs, 1957;Mustakallio and Kalliomaki, 1968).…”

Hemolytic and Conglutinating Complement in Normal and Pathologic Human Sera

“…On the other hand, the distinct rise of Cc titers in rheumatoid arthritis observed in the present study, is in agreement with the concept outlined. In this disease we had earlier found elevated immunoconglutinin titers (8). Rheumatoid arthritis sera are generally known to behave very differently as regards the CH titers.…”