1953
DOI: 10.1136/ard.12.2.88
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Observations on the Treatment of Rheumatoid Arthritis with Butazolidin

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1953
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Cited by 22 publications
(7 citation statements)
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“…Currie et al (1953) and Brodie, Lowman, Burns, Lee, Chenkin, Goldman, Weiner & Steele (1954) noted a relationship between plasma level and clinical effect but recently Davies, Orme, Williams, Hughes & Holt (1973) failed to demonstrate this relationship conclusively.…”
Section: Introductionmentioning
confidence: 97%
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“…Currie et al (1953) and Brodie, Lowman, Burns, Lee, Chenkin, Goldman, Weiner & Steele (1954) noted a relationship between plasma level and clinical effect but recently Davies, Orme, Williams, Hughes & Holt (1973) failed to demonstrate this relationship conclusively.…”
Section: Introductionmentioning
confidence: 97%
“…Phenylbutazone was introduced in 1952 and has established itself as an efficacious anti-inflammatory agent for the treatment of rheumatoid arthritis (Currie, Peebles-Brown & Will, 1953;Mason, Barnardo, Fox & Weatherall, 1967;Lewis-Faning & Fowler, 1971). Currie et al (1953) and Brodie, Lowman, Burns, Lee, Chenkin, Goldman, Weiner & Steele (1954) noted a relationship between plasma level and clinical effect but recently Davies, Orme, Williams, Hughes & Holt (1973) failed to demonstrate this relationship conclusively.…”
Section: Introductionmentioning
confidence: 99%
“…In 3 of these cases (6 per cent ) the toxic reaction was of a major nature ancd necessitated discontinuing the drtug. 4. The average dose schedtule was 600 nmg.…”
Section: Toxicitymentioning
confidence: 99%
“…4 Clinically, however it has been notedl that the miaximumtii benefit is most often reached in 36 to 48 hours after treatment has been started. 4 Because of its ability to produce sodium retentioni with edema, phenylbutazone has been susl)ected of possessing a hormonal action similar to cortisone or corticotropin.…”
mentioning
confidence: 99%
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