Observations on the treatment of natural haemosporidia infections by total alkaloid ofPeganum harmala L. in cattle

Hu, Ting‐Jun; Fan, Bingtang; Liang, Jilan; Zhao, Sixi; Dang, Ping; Gao, Fang; Dong, Mingxian

doi:10.1007/bf02632936

Cited by 12 publications

(7 citation statements)

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“…The reasons for this apparent discrepancy in the success rate of the treatment in our experiment and that of Mirzaie & Shaddel (2004) could be the different environmental conditions in which their sheep were maintained, the small numbers of sheep they used and the fact that the infection was experimentally induced. Our results are in agreement with that of other experiments in which the alkaloids of P. harmala were used for the treatment of tropical theileriosis in cattle (Agaev, Mirzabekov, Gumbatov & Mirzabekov 1977;Vecherkin, Puzii, Romakhov & Tribunskii 1977;Charyev & Khudaiberdyev 1978;Levchenko 1978Levchenko , 1979Puzii, Vetchorkin, Romakhov & Vecherkin 1979;Puzii, Vecherkin, Toptaev, Tsyganova & Duisheev 1982;Fan et al 1997;Hu et al 1997).…”

Section: Discussionsupporting

confidence: 92%

“…Tests have shown that these two compounds are effective (Hooshmand-Rad 1989) but they are not easily and quickly eliminated from the body of animals (McHardy, Wekesa, Hudson & Randall 1985) which can constitute a public health hazard if milk and meat of treated animals are consumed by humans. The therapeutic effect of the alka loids of the plant Peganum harmala has been investigated for the treatment of tropical theileriosis in cattle which is caused by Theileria annulata and it was shown that they are effective (Fan, Liang, Men, Gao, Li, Zhao, Hu, Dang, Zhang, Preston & Yin 1997;Hu, Fan, Liang, Zhao, Dang, Gao, Dong, Preston & Yin 1997) In addition, it has been shown that these alkaloids, when inoculated intramuscularly do not infiltrate the muscular tissue surrounding the inoculation site but are also rapidly eliminated from the body (Puzii & Serov 1983). The objective of this study was to study the effect of total alkaloids of P. harmala when used for the treatment of naturally infected cases of ovine malignant theileriosis.…”

Section: Introductionmentioning

confidence: 99%

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Treatment of natural ovine malignant theileriosis with a chloroform extract of the plant Peganum harmala : research communication

Mirzaiedehaghi¹

2006

Onderstepoort J Vet Res

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Treatment of natural ovine malignant theileriosis with a chloroform extract of the plant Peganum harmala : research communication

Mirzaiedehaghi¹

2006

Onderstepoort J Vet Res

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“…Our results are in agreement with those of other experiments in which the alkaloids of P. harmala were used for the treatment of tropical theileriosis in cattle (Agaeve, Mirzabekov, Gumbatov & Mirzabekov 1977;Vecherkin, Puzii, Romakhov & Tribunskii 1977;Charyev & Khudaiberdyev 1978;Levchenko 1978Levchenko , 1979Puzii, Vetchorkin, Romakhov & Vecherkin 1979;Puzii, Vecherkin, Toptaev, Tsyganova & Duisheev 1982;Fan et al 1997;Hu et al 1997). The pathologic findings of the lambs in Group B confirmed that they had died of malignant theileriosis (Radostits, Gay, Blood & Hinchcliff 2000).…”

Section: Discussionsupporting

confidence: 92%

“…Among the several alkaloids, harmaline (harmidine, C 13 H 14 N 2 O) has been found to be the major active alkaloid which can cause cell death due to non-specific membrane damage (Budavari & O'Neil 1996;Lala, Pramanick, Mukhopadhyay, Bandyopadhyay & Basu 2004). The therapeutic effect of the alkaloids of the plant Peganum harmala has been investigated for the treatment of tropical theileriosis in cattle, which is caused by Theileria annulata, and in sheep naturally infected with Theileria hirci; it was shown that they are effective (Fan, Liang, Men, Gao, Li, Zhao, Hu, Dang, Zhang, Preston & Yin 1997;Hu, Fan, Liang, Zhao, Dang, Gao, Dong, Preston & Yin 1997;Mirzaie dehaghi 2006). In addition, it has been shown that these alkaloids, when inoculated intramuscularly, do not infiltrate the muscular tissue surrounding the inoculation site but are rapidly eliminated from the body (Puzii & Serov 1983).…”

Section: Peganum Harmala Lmentioning

confidence: 99%

Effect of Peganum harmala (wild rue) extract on experimental ovine malignant theileriosis : pathological and parasitological findings

Derakhshanfar¹,

Mirzaei²

2008

Onderstepoort J Vet Res

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Malignant theileriosis of sheep is a highly fatal, acute or subacute disease is caused by the tick-borne protozoan parasite, Theileria hirci. In this investigation ten healthy male lambs aged 5-6 months were randomly divided into two groups, A and B and were kept in isolated tick-proof pens. They were treated for internal and external parasite before commencement of the experiment. The lambs were experimentally infected with T. hirci by placing ticks Hyalomma anatolicum anatolicum infected with T. hirci on them. The ticks used in this survey had originally been isolated from sheep and colonies of them were established in an insectarium. Before and after infection rectal temperatures and clinical signs of the lambs were recorded, blood and prescapular lymph node smears were prepared and examined to determine the extent of the parasitaemia, and blood samples were analyzed to evaluate their haemoglobin (Hb) and packed cell volume (PCV) rates. Three days after the commencement of a febrile reaction and appearance of the schizonts in the lymph node smears, treatment of the lambs in Group A with an extract containing the alkaloids of Peganum harmala (wild rue) was commenced. Group B lambs were kept untreated controls. Before treatment there were no significant differences in the rectal temperature, parasitaemia rate, and the Hb and PCV values between animals in the two groups but after treatment significant differences in these values was detected (P < 0.05). After treatment, the clinical signs and parasites in the lymph node smears of the animals in Group A disappeared and they all animals recovered. These parameters in the animals of Group B progressed until their death. Pathological studies showed the characteristic lesions of theileriosis in lambs in Group B, but not in Group A. The results indicate a therapeutic effect of the alkaloids of P. harmala for treatment of ovine malignant theileriosis.

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“…The alkaloids in the seed extract have been utilized to control hemosporidian infection in naturally and experimentally infected cattle Hu et al, 1997). Until now, the effect of Peganum harmala seed extract was only studied in mammalian models, and its therapeutic doses have been reported to be safe for rodents (Lamchouri et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Peganum harmala Can Minimize Escherichia coli Infection in Poultry, but Long-Term Feeding May Induce Side Effects

et al. 2008

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Peganum harmala seed extracts have been frequently reported to possess antibacterial potential through in vitro studies, but in vivo studies have acquired less attention. The present study was therefore designed to investigate its efficacy on the course of colibacillosis and effects of long-term feeding on selected parameters of general health in chickens. Two experiments were conducted in this regard. Experiment 1 (a pilot study) was performed to determine the dose of a field strain of Escherichia coli (O1:K1) required to induce clinical symptoms in 4- and 15-d-old specific-pathogen-free chickens. A successful induction of colibacillosis, in terms of clinical signs, mortality, and pathological lesions in addition to reisolation of the pathogen was observed by inoculating 4- and 15-d-old chicks with 4.3 log(10) and 6.4 log(10) cfu of E. coli, respectively, by intraperitoneal injection. Using these doses experiment 2 (main study) consisting of a single experiment with 3 parts was performed. Parts A and B generated the information regarding efficacy of the extract against infection in 4- and 15-d-old chickens applying different treatment schemes, whereas the effects of continuous feeding of the extract were assessed in part C. Whereas no protective effect of the extract could be recorded in young chickens, significant differences (P < 0.05) with regard to BW, clinical score, gross lesion score, and total granulocyte counts were observed in 15-d-old birds. Bacterial recovery per gram of tissue and reisolation frequency were lower in treated birds. The continuous feeding of the extract for 6 wk resulted in an augmentation in relative liver weight and depletion in alkaline phosphatase, protein, albumin, and globulin. It can be concluded that the crude extract of Peganum harmala possesses limited antimicrobial activity against E. coli in vivo and long-term continuous feeding may induce undesired effects. Furthermore, the study underlines the value of in vivo experiments and the diverse picture that herbal products, in this case Peganum harmala, may deliver by testing them against specific pathogens.

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Observations on the treatment of natural haemosporidia infections by total alkaloid ofPeganum harmala L. in cattle

Cited by 12 publications

References 0 publications

Treatment of natural ovine malignant theileriosis with a chloroform extract of the plant <i>Peganum harmala</i> : research communication

Treatment of natural ovine malignant theileriosis with a chloroform extract of the plant <i>Peganum harmala</i> : research communication

Effect of <i>Peganum harmala</i> (wild rue) extract on experimental ovine malignant theileriosis : pathological and parasitological findings

Peganum harmala Can Minimize Escherichia coli Infection in Poultry, but Long-Term Feeding May Induce Side Effects

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