Observations relating to psychosin sulphate: Its action upon bacteria, toxins, serum and red blood cells

Drury, A. N.; Miles, J. A. R.; Platt, A. E.; Plaut, G.W.E.; Weil, Hans-Peter; Hughes, Arlene R.

doi:10.1002/path.1700420205

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Destruction Of Toxin By Psychosine Sulphate1

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1936

1959

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Cited by 4 publications

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“…Drury et al (1936) showed that psychosine sulphate inactivated tetanus toxin but not other toxins. This observation has been confirmed in so far as a solution containing 150 pg.…”

Section: Destruction Of Toxin By Psychosine Sulphatementioning

confidence: 99%

The Fixation of Tetanus Toxin by Nervous Tissue

Heyningen

1959

Journal of General Microbiology

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SUMMARY:The fixation of tetanus toxin by nervous tissue ( Wassermann-Takaki phenomenon, 1898) has been re-investigated. Fixation is greatly dependent on the concentration of toxin and of receptor. Toxin is fixed in preference to toxoid, but its toxicity does not appear to be markedly diminished by fixation. A biological assay of the toxin receptor in nervous tissue and its components has been devised. The receptor activity is not due to a cerebroside, as thought by Landsteiner & Botteri (1906), but to some substance (present mainly in grey matter) that tends to associate with it.

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“…Drury et al (1936) showed that psychosine sulphate inactivated tetanus toxin but not other toxins. This observation has been confirmed in so far as a solution containing 150 pg.…”

Section: Destruction Of Toxin By Psychosine Sulphatementioning

confidence: 99%

The Fixation of Tetanus Toxin by Nervous Tissue

Heyningen

1959

Journal of General Microbiology

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“…McKee (1915) and Ponder (1921) found in human urine a lytic factor which was soluble in organic solvents and which it was suggested might be a bile acid or some related compound. Drury & Weil (1934) and Drury, Miles, Platt, Plaut, Weil & Hughes (1936) studied the lytic action of psychosin (lignoceryl sphingosine), and showed that it was lost on deamination; however, no evidence could be found that psychosin, or even sphingosine, existed in the free state in animals. Bergenhem & FAhraeus (1936) reported the presence of a haemolytic substance in normal blood and, on rather slender evidence, suggested tha;t it was a lysolecithin derivative.…”

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confidence: 99%