Observed birth prevalence of congenital anomalies among live births at a regional facility in KwaZulu Natal Province, South Africa

Saib, Muhammad Zubayr; Dhada, Barnesh; Aldous, Colleen; Malherbe, Helen

doi:10.1371/journal.pone.0255456

Cited by 8 publications

(16 citation statements)

References 19 publications

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“…More than half of the neonates with CA had birth weights greater than 2.5kg as also observed in other parts of Nigeria [9,18] and Africa [24,29]. This finding in the present study is not surprising as most neonates with CA were delivered at term ie gestational age of 37-42weeks.…”

Section: Ga=gestational Age; Dama=discharged Against Medical Advicesupporting

confidence: 85%

“…There was slight male preponderance in the present study. Similar male preponderance was also documented by Ekwunife et al [17], Ajao & Adeyemo [9], Ayede et al [27], Mushuda et al [28], Saib et al [29], Abdolahi et al [30] and Abdou et al [31]. In contrast, female preponderance was documented by Tunde-Oremode et al [22] and Wagathu & Ongeso [24].…”

Section: Ga=gestational Age; Dama=discharged Against Medical Advicesupporting

confidence: 76%

“…Polydactyl was the commonest individual CA observed in the present study followed by congenital heart diseases and congenital talipes equinovarus. Polydactyl was also observed by Saib et al [29] in South Africa as the commonest individual CA. In Yenagoa [22] Southern Nigeria however, Ventricular septal defect was the commonest individual CA observed.…”

Section: Ga=gestational Age; Dama=discharged Against Medical Advicesupporting

confidence: 69%

“…This is not a surprising finding as smoking is not a common habit in Africa as compared to the Western countries. [18,32] Eastern Nigeria, Kenya [24], South Africa [29], Iran [39] and India [40,41,42]. Contrary to the present study, anomalies of the cardiovascular system was documented as the commonest anomalies in Ogbomoso [9], Western Nigeria and Yenagoa [22], Southern Nigeria whereas anomalies of the central nervous system was the commonest in an earlier study in Port Harcourt [43] carried out about a decade ago, Iraq [20], Tanzania [28], Iran [30] and Ondo State [38] Western Nigeria.…”

Section: Ga=gestational Age; Dama=discharged Against Medical Advicementioning

confidence: 99%

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Prevalence, Pattern and Outcome of Congenital Anomalies among Babies Admitted in a Neonatal Unit in Southern Nigeria

West

Okari

2021

IJTDH

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Aim: This study was carried out to determine the prevalence, pattern and outcome of congenital anomalies among neonates admitted in the neonatal unit of the Rivers State University Teaching Hospital. Study Design: A prospective study. Place and Duration of Study: This study was carried out in the Special Care Baby Unit of the Rivers State University Teaching Hospital over a three-year period from 1st June 2018 to 31st May 2021. Methodology: A questionnaire was used to collect data on the babies with congenital anomalies from their mothers/caregivers. Data was analysed using SPSS version 23. Fishers’ Exact test was adopted to determine the association between some congenital anomalies and the variables. Results: The prevalence of congenital anomalies in the study period was 5.5%, more preponderant among males 48(50.5%), term babies 56(58.9%) and among singleton pregnancies 82(86.3%). Most of the anomalies were major defects 66(69.5%), occurred more frequently in the musculoskeletal system 36 (33%), cardiovascular (13.8%) and urogenital systems (13.8%). Hypertension (30.3%) and diabetes mellitus in pregnancy were the commonest complications of pregnancy found among mothers whose babies had congenital anomalies. Seven (7.4%) babies with birth anomalies died in the study. There was no significant association of sex, gestational age, birth weight with congenital anomalies (P value > .05). Conclusion: The prevalence of congenital anomalies in this study was low being 5.5%. Although majority of the babies had major defects, the neonatal outcome was fair with mortality of 7.4%.

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Section: Ga=gestational Age; Dama=discharged Against Medical Advicesupporting

confidence: 85%

Section: Ga=gestational Age; Dama=discharged Against Medical Advicesupporting

confidence: 76%

Section: Ga=gestational Age; Dama=discharged Against Medical Advicesupporting

confidence: 69%

Section: Ga=gestational Age; Dama=discharged Against Medical Advicementioning

confidence: 99%

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Prevalence, Pattern and Outcome of Congenital Anomalies among Babies Admitted in a Neonatal Unit in Southern Nigeria

West

Okari

2021

IJTDH

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“…In this systematic review and meta-analysis, 60 articles, which included about 3,091,946 births and 52,569 congenital anomalies, were analyzed. Of these, 4 studies were conducted in Ethiopia [30][31][32][33]; 16 studies were conducted in Nigeria [34][35][36][37][38][39][40][41][42][43][44][45][46][47][48]; 9 studies were conducted in Egypt [49][50][51][52][53][54][55][56][57][58][59]; 3 studies were conducted in South Africa [60][61][62][63][64]; 5 studies were conducted in Morocco [65][66][67][68][69]; 6 studies were conducted in Libya [70][71][72][73][74][75]; 2 studies were conducted in Tunisia [76][77]…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Proportion of Chromosomal Disorders and Their Patterns among Births with Congenital Anomalies in Africa: A Systematic Review and Meta-Analyses

Gebremeskel

Gedion

2022

The Scientific World Journal

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Introduction. Worldwide, surveys have shown that the frequency of chromosomal disorders among births with congenital anomalies varies greatly from country to country. It is well known that chromosomal disorders are an important cause of premature death or life-long disability; however, the absence of local epidemiological data on their birth prevalence and outcomes impedes policy and service development in many countries and continents. Therefore, the current systematic review and meta-analysis intend to show the pooled proportion of chromosomal disorders among births with congenital anomalies in Africa. Methods. From PubMed, Cochrane Library, and Google Scholar, we systematically reviewed and meta-analyzed the studies that examined the incidence, prevalence, and types of chromosomal disorders using PRISMA guidelines. A weighted inverse variance random-effects model was used to estimate the pooled proportion of chromosomal disorders among births with congenital anomalies. Results. From the total of 3,569 studies identified, 1,442 were from PubMed, 108 were from Cochrane Library, 1,830 were from Google Scholar, and 189 were from other sources. After duplication was removed, a total of 844 articles remained (2725 were removed by duplication). Finally, 144 full-text studies were reviewed and 60 articles with 52,569 births having congenital anomalies met the inclusion criteria and were selected for this meta-analysis. The pooled proportion of chromosomal disorders among births with congenital anomalies was 8.94% (95% CI; 7.02, 10.86; I2 = 98.8%; p < 0.001 ). Conclusions and Future Implications. In the current systematic review and meta-analysis, the pooled proportion of chromosomal disorders among births with congenital anomalies in Africa was small. Down syndrome (trisomy 21) accounted for more than 80% of chromosomal disorders. The pooled proportion of chromosome disorders was the highest in North African regions and countries compared to other regions of the continent. Healthcare managers should focus on establishing proper cytogenetic diagnostic facilities in collaboration with well-trained genetic counseling services in the continent.

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Birth prevalence and risk factors of neural tube defects in Ethiopia: a systematic review and meta-analysis

Tesfay,

Hailu,

Habtetsion

et al. 2023

BMJ Open

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ObjectiveThis study aims to estimate the prevalence of neural tube defects (NTDs) and to identify potential risk factors in the Ethiopian context.Study designSystematic review and meta-analysis.Study participantsA total of 611 064 participants were included in the review obtained from 42 studies.MethodsPubMed (Medline), Embase and Cochrane Library databases in combination with other potential sources of literature were systematically searched, whereby studies conducted between January 2010 and December 2022 were targeted in the review process. All observational studies were included and heterogeneity between studies was verified using Cochrane Q test statistics and I2test statistics. Small study effects were checked using Egger’s statistical test at a 5% significance level.ResultThe pooled prevalence of all NTDs per 10 000 births in Ethiopia was 71.48 (95% CI 57.80 to 86.58). The between-study heterogeneity was high (I2= 97.49%, p<0.0001). Birth prevalence of spina bifida (33.99 per 10 000) was higher than anencephaly (23.70 per 10 000), and encephalocele (4.22 per 10 000). Unbooked antenatal care (AOR 2.26, 95% CI (1.30 to 3.94)), preconception intake of folic acid (AOR 0.41, 95% CI (0.26 to 0.66)), having chronic medical illness (AOR 2.06, 95% CI (1.42 to 2.99)), drinking alcohol (AOR 2.70, 95% CI (1.89 to 3.85)), smoking cigarette (AOR 2.49, 95% CI (1.51 to 4.11)), chewing khat (AOR 3.30, 95% CI (1.88 to 5.80)), exposure to pesticides (AOR 3.87, 95% CI (2.63 to 5.71)), maternal age ≥35 (AOR 1.90, 95% CI (1.13 to 3.25)), maternal low educational status (AOR 1.60, 95% CI (1.13 to 2.24)), residing in urban areas (AOR 0.75, 95% CI (0.58 to 0.97))and family history of NTDs (AOR 2.51, 95% CI (1.36 to 4.62)) were associated with NTD cases.ConclusionThe prevalence of NTDs in Ethiopia is seven times as high as in other Western countries where prevention measures are put in place. Heredity, maternal and environmental factors are associated with a high prevalence of NTDs. Mandatory fortification of staple food with folic acid should be taken as a priority intervention to curb the burden of NTDs. To smoothen and overlook the pace of implementation of mass fortification, screening, and monitoring surveillance systems should be in place along with awareness-raising measures.PROSPERO registration numberCRD42023413490.

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Observed birth prevalence of congenital anomalies among live births at a regional facility in KwaZulu Natal Province, South Africa

Cited by 8 publications

References 19 publications

Prevalence, Pattern and Outcome of Congenital Anomalies among Babies Admitted in a Neonatal Unit in Southern Nigeria

Prevalence, Pattern and Outcome of Congenital Anomalies among Babies Admitted in a Neonatal Unit in Southern Nigeria

Proportion of Chromosomal Disorders and Their Patterns among Births with Congenital Anomalies in Africa: A Systematic Review and Meta-Analyses

Birth prevalence and risk factors of neural tube defects in Ethiopia: a systematic review and meta-analysis

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