Observed changes in brown, white, hepatic and pancreatic fat after bariatric surgery: Evaluation with MRI

Hui, Steve C.N.; Wong, Sunny Kit-Man; Ai, Qi Yong H.; Yeung, David W. K.; Ng, Enders K.; Chu, Winnie C.W.

doi:10.1007/s00330-018-5611-z

Cited by 38 publications

(26 citation statements)

References 39 publications

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“…The MRI acquisition for abdominal subcutaneous and visceral adipose tissue measurements was performed from the dome of the diaphragm to the pubic symphysis. The authors found that within 12 months after surgery, subcutaneous adipose tissue volume decreased by 34.5% and visceral adipose tissue volume by 51.2%, mostly in the first 6 months following surgery [25]. The study using whole-body MRI showed that relative loss was significantly higher for visceral than for subcutaneous adipose tissue (52.3 vs. 42.3%) 12 months following bariatric surgery [21].…”

Section: Discussionmentioning

confidence: 99%

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The Influence of Laparoscopic Sleeve Gastrectomy on Body Composition and Fat Distribution in Obese Caucasian Men and Women

et al. 2020

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Background The aim of the study was to assess changes in body composition in patients subjected to laparoscopic sleeve gastrectomy (LSG). Methods Changes in body composition following LSG were determined in a group of 155 patients with obesity (117 women and 38 men), with dual-energy X-ray absorptiometry (DXA). Whole body fat mass (FM) and lean body mass (LBM) were determined, and abdominal fat mass (AbdF) was assessed within the region extending from the top of the pubic bone up to the line between 12th thoracic and 1st lumbar vertebras. Results Over the period of 12 months following LSG, body mass index decreased by 28.2 ± 9.0% (p < 0.001). The reduction of body weight by 35.4 ± 12.6 kg (p < 0.001) was the result of a decrease in FM by 23.9 ± 8.9 kg (p < 0.001) and LBM by 10.5 ± 3.8 kg (p < 0.001). AbdF decreased from 13.2 ± 3.1 to 8.2 ± 2.7 kg (p < 0.001), but abdominal fat to total fat mass ratio increased from 24.9 ± 4.7 to 28.0 ± 5.8% (p < 0.001). The loss of AbdF was more pronounced in men than in women. The rate of FM loss was attenuated with patients' age. Conclusions Over the period of 12 months following LSG, the reduction of FM was more than twice as much as decrease of LBM. The loss of AbdF was slower than a loss of peripheral subcutaneous fat.

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Section: Discussionmentioning

confidence: 99%

“…In the previous studies a higher relative reduction of visceral fat as compared to other compartments was observed [23][24][25][26]. The authors of Swedish study examined body composition of 166 women before and 2 years after RYGB.…”

Section: Discussionmentioning

confidence: 99%

The Influence of Laparoscopic Sleeve Gastrectomy on Body Composition and Fat Distribution in Obese Caucasian Men and Women

et al. 2020

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“…Our recent research (Abe et al, ) indicated that the percentage of the fat fraction in subcutaneous adipose tissue was 87.1% in nonobese adults (BMI range 21.7‐24.6 kg/m 2 ). In severely obese patients (BMI 35 kg/m 2 ), a study reported that fat fraction percentage of subcutaneous adipose tissue was 84.4% (range 82.3‐85.7%) (Hui et al, ). There are only a few studies regarding the fat fraction percentage separated by sex and the results were inconsistent; one study observed a significant difference between men and women (Jones et al, ), but another did not (Hui et al, ).…”

Section: Discussionmentioning

confidence: 99%

Skeletal muscle mass in female athletes: The average and the extremes

Abe

Wong

Dankel

et al. 2019

American J Hum Biol

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Objectives To examine the absolute and relative skeletal muscle mass (SM) in female athletes and to discuss the potential upper limit of whole‐body muscle mass between large sized female and male athletes. Methods Forty‐five female athletes and forty‐five recreationally active females (control) had muscle thickness measured by ultrasound at nine sites on the anterior and posterior aspects of the body. SM was estimated from an ultrasound‐derived prediction equation. Body fat percentage and fat‐free mass (FFM) were calculated from ultrasound measured subcutaneous fat thickness. To eliminate fat‐free component of adipose tissue (FFAT), we calculated FFM minus FFAT (FFM‐FFAT). Results FFM, FFM‐FFAT, and muscle mass were markedly higher in athletes. Fat Mass was similar (Athlete: 14.9 kg vs Control: 12.9 kg [median value]). The large‐sized female athletes had approximately 9 to 11 kg FFAT which corresponds to about 10% to 15% of FFM. Seven of the female athletes had more than 60 kg of FFM‐FFAT, the largest of whom had 77.0 kg of FFM‐FFAT. SM increased in a parabolic fashion reaching a value of 35 kg SM beyond 100 kg body mass. Only one of the athletes had a SM index of more than 13 kg/m2. Conclusions Female athletes had much greater muscle mass than controls. In large‐sized female athletes, the influence of FFAT needs to be considered when interpreting their FFM. In addition, the largest SM index in female athletes was 13.2 kg/m2, which was approximately 77% of that observed with the largest male athlete ever recorded. This difference appears similar to that observed in nonathletes.

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“…Future investigations of the underlying mechanisms to the association between BAT and 2h glucose in adolescents are warranted. Also, changes in sBAT FF and

T_{2}^{*}

before and after intervention, eg, bariatric surgery as recently studied, are potential topics for forthcoming studies.…”

Section: Discussionmentioning

confidence: 99%

Brown adipose tissue estimated with the magnetic resonance imaging fat fraction is associated with glucose metabolism in adolescents

et al. 2019

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Summary Background Despite therapeutic potential against obesity and diabetes, the associations of brown adipose tissue (BAT) with glucose metabolism in young humans are relatively unexplored. Objectives To investigate possible associations between magnetic resonance imaging (MRI) estimates of BAT and glucose metabolism, whilst considering sex, age, and adiposity, in adolescents with normal and overweight/obese phenotypes. Methods In 143 subjects (10‐20 years), MRI estimates of BAT were assessed as cervical‐supraclavicular adipose tissue (sBAT) fat fraction (FF) and T2* from water‐fat MRI. FF and T2* of neighbouring subcutaneous adipose tissue (SAT) were also assessed. Adiposity was estimated with a standardized body mass index, the waist‐to‐height ratio, and abdominal visceral and subcutaneous adipose tissue volumes. Glucose metabolism was represented by the 2h plasma glucose concentration, the Matsuda index, the homeostatic model assessment of insulin resistance, and the oral disposition index; obtained from oral glucose tolerance tests. Results sBAT FF and T2* correlated positively with adiposity before and after adjustment for sex and age. sBAT FF, but not T2*, correlated with 2h glucose and Matsuda index, also after adjustment for sex, age, and adiposity. The association with 2h glucose persisted after additional adjustment for SAT FF. Conclusions The association between sBAT FF and 2h glucose, observed independently of sex, age, adiposity, and SAT FF, indicates a role for BAT in glucose metabolism, which potentially could influence the risk of developing diabetes. The lacking association with sBAT T2* might be due to FF being a superior biomarker for BAT and/or to methodological limitations in the T2* quantification.

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Observed changes in brown, white, hepatic and pancreatic fat after bariatric surgery: Evaluation with MRI

Cited by 38 publications

References 39 publications

The Influence of Laparoscopic Sleeve Gastrectomy on Body Composition and Fat Distribution in Obese Caucasian Men and Women

The Influence of Laparoscopic Sleeve Gastrectomy on Body Composition and Fat Distribution in Obese Caucasian Men and Women

Skeletal muscle mass in female athletes: The average and the extremes

Brown adipose tissue estimated with the magnetic resonance imaging fat fraction is associated with glucose metabolism in adolescents

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