In this paper, the fault estimation and intermittent control of nonlinear multiagent systems with multiple disturbances based on transition variable are studied. This paper realizes fault estimation by designing a transition variable-based estimator. Considering the working intensity of the actuator and the nonlinear and multiple state related disturbance in a non-ideal state, intermittent control is introduced to extend the service life of the controller, and the system state observer is designed. Then, an augmented system model is established, and a sufficient condition is derived. Next, system state observer gain, transition variable-based estimator gain, and controller gain are given. Finally, the simulation results show that the proposed method can make the multiagent system achieve consensus, and the designed intermittent observer and transition variable-based fault estimator are effective.