In order to improve the safety and reliability of the hypersonic flight vehicle, a sliding mode observer-based fault detection scheme is applied in this paper to handle the actuator fault detection issue, including stuck fault detection and PLOE fault detection. A dynamic linear model with uncertainty is first derived from the original nonlinear hypersonic flight vehicle model by using Taylor’s linearization approach at the equilibrium point. Secondly, the actuator fault model, reflecting stuck faults and PLOE faults, is constructed. Then, a sliding mode-based fault detection observer, considering system decomposition, is developed based on the linearized hypersonic flight vehicle model. At last, the designed sliding mode observer is applied to the original nonlinear hypersonic flight vehicle for single-input, single-style actuator fault detection. The simulation results show that stuck faults and big proportion PLOE faults can be timely and accurately detected at the fault time, and the stuck actuator fault from input 3 can cause a deadly impact to the hypersonic flight vehicle, which deserves much more attention than the actuator faults from the other three inputs. Meanwhile, the detection of a small proportion of PLOE faults encounters some difficulties and needs special attention and further investigation.