The Current State. The Sun and heliosphere is a system-of-systems: the solar interior/dynamo; the solar atmosphere, consisting of the photosphere, chromosphere, transition region, low, middle and upper corona; and the solar wind/heliosphere. Cross-regional and cross-scale coupling is crucial to the physical state of this system. Emergent phenomena, i.e., physical behaviors that emerge only when the parts interact in a wider whole, are revealed when studying cross-scale and cross-regional feedback. The Sun's magnetic field, generated in the solar interior, and threading through the solar atmosphere and out into solar wind, produces much of the coupling. Due to the complexity and feedback of this system-of-systems, there are major outstanding questions regarding solar wind formation, and its evolution as it advects through the heliosphere. Synthesizing inputs from the solar wind research community, nine outstanding questions of solar wind physics from a recent AGU Grand Challenges review paper (Viall & Borovsky 2020) are described in this white paper, as well as potential solutions. The formation of the solar wind and its evolution as it flows away from the Sun is fundamental to how the Sun and stars get rid of stressed magnetic fields, and involves physical processes that operate throughout the universe. Additionally, the solar wind constantly bombards Earth's magnetic field and plasma environment, as well as other planetary bodies, driving dynamic space weather. The solar wind is the medium through which larger space weather events from solar storms (e.g. CMEs and SEPs) propagate. Understanding the solar wind is therefore key for understanding universal plasma physics, stars and how they form their astrospheres, and space weather and the space environment around Earth.