Obsessions in Their Relation to Psychoses

Gordon, Alfred

doi:10.1176/ajp.82.4.647

Cited by 20 publications

(6 citation statements)

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“…In addition to reflecting a deficit in gating information relating to an unexpected stimulus, failure to attend to a competing stimulus could also reflect an alteration in salience processing resulting in obsessive fixation on the goal-directed behavior. Indeed, obsessions in psychosis have been described for decades (Gordon, 1926) and alterations in dopamine-dependent regulation of salience processes have been proposed as a major contributor to psychotic behavior (Kapur, 2003). Further exploration into the role of altered dopamine neuron activity patterns in the processing of salient information in the prefrontal cortex and nucleus accumbens will shed further light on this subject.…”

Section: Discussionmentioning

confidence: 99%

Disruption of Dopamine Neuron Activity Pattern Regulation through Selective Expression of a Human KCNN3 Mutation

Soden

Jones

Sanford

et al. 2013

Neuron

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Summary The calcium-activated small conductance potassium channel, SK3, plays an essential role in the regulation of dopamine neuron activity patterns. Here we demonstrate that expression of a human disease-related SK3 mutation (hSK3Δ) in dopamine neurons of mice disrupts the balance between tonic and phasic dopamine neuron activity. Expression of hSK3Δ suppressed endogenous SK currents, reducing coupling between SK channels and NMDA receptors (NMDARs) and increasing permissiveness for burst firing. Consistent with enhanced excitability of dopamine neurons, hSK3Δ increased evoked calcium signals in dopamine neurons in vivo and potentiated evoked dopamine release. Specific expression of hSK3Δ led to deficits in attention and sensory gating and heightened sensitivity to a psychomimetic drug. Sensory-motor alterations and psychomimetic sensitivity were recapitulated in a mouse model of transient, reversible dopamine neuron activation. These results demonstrate the cell-autonomous effects of a human ion channel mutation on dopamine neuron physiology and the impact of activity pattern disruption on behavior.

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Section: Discussionmentioning

confidence: 99%

Disruption of Dopamine Neuron Activity Pattern Regulation through Selective Expression of a Human KCNN3 Mutation

Soden

Jones

Sanford

et al. 2013

Neuron

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“…Since the early 1900s, obsessive–compulsive symptoms (OCS) have been consistently described as a distinguishing feature of patients suffering from psychosis (Gordon, 1926; Stengel, 1945; Pious, 1950; Rosen, 1957). Bleuler (1950), one of the contributors to the definition of schizophrenia, also mentioned OCS as a feature of schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

Clinical and neurocognitive profiles of subjects at high risk for psychosis with and without obsessive–compulsive symptoms

Hur

Shin²,

Jang

et al. 2012

Aust N Z J Psychiatry

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“…The link between obsessive-compulsive symptomatology and psychosis has been noted since the early 20 th century (Gordon, 1926; Stengel, 1945). Prevalence rates for obsessive-compulsive disorder (OCD) as high as 30% have been reported in schizophrenia populations (Byerly et al, 2005), as compared to 1.2-2.4% in the normal population (Foa et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

Obsessive compulsive symptoms in the psychosis prodrome: Correlates of clinical and functional outcome

Niendam

Berzak

Cannon

et al. 2009

Schizophrenia Research

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Objectives Obsessive-Compulsive Disorder (OCD) is a common co-morbid condition in schizophrenia, associated with poor prognosis. However, the prevalence of obsessive compulsive symptomatology (OCS) and its relationship to outcome has not been evaluated in adolescents at ultra high-risk for psychosis (UHR). Methods Sixty-four UHR and 26 non-prodromal comparison (NPC) youth were ascertained using the Structured Interview for Prodromal Syndromes (SIPS). Participants completed diagnostic interviews and the Padua Inventory (Sanavio, 1988), a self-report measure of OCS. Results UHR youth reported significantly higher rates of OCS on the Padua Inventory compared to NPC youth. Clinical diagnosis of OCD (20% of sample) was associated with lower risk of conversion to psychosis over the follow-up period, but was unrelated to clinical severity or psychosocial functioning. However, dimensional ratings of OCS were significantly associated with positive symptom severity, self-reported depression, and a trend toward increased suicidal ideation within the UHR sample. Conclusions OCS rates in UHR youth are well above estimated prevalence rates in normal populations, and commensurate with rates of comorbidity observed in schizophrenia. Although clinical diagnosis of OCD was not associated with later conversion to psychosis, OCS severity in UHR youth was associated with more acute symptomatic presentation, including more severe depression and suicidality.

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Obsessions in Their Relation to Psychoses

Cited by 20 publications

References 0 publications

Disruption of Dopamine Neuron Activity Pattern Regulation through Selective Expression of a Human KCNN3 Mutation

Disruption of Dopamine Neuron Activity Pattern Regulation through Selective Expression of a Human KCNN3 Mutation

Clinical and neurocognitive profiles of subjects at high risk for psychosis with and without obsessive–compulsive symptoms

Obsessive compulsive symptoms in the psychosis prodrome: Correlates of clinical and functional outcome

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