Obsessive compulsive disorder

Thapar, Anita; Pine, Daniel S.; Leckman, James F.; Scott, Stephen; Snowling, Margaret J.; Taylor, Eric

doi:10.1002/9781118381953.ch61

Cited by 9 publications

(5 citation statements)

References 147 publications

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“…Also, family life comes to be dominated by other family members' attempts to accommodate to, or prevent these rituals. Meta-analyses and narrative reviews have shown that familybased, cognitive behavioural, exposure and response prevention treatment is effective in alleviating symptoms in 50 to 70 per cent of cases of paediatric OCD; that the best treatment response occurs where such interventions are combined with selective serotonin reuptake inhibitors (SSRI) such as Sertaline; and that family-based CBT is more effective than SSRIs alone (Franklin et al, 2017;McGuire et al, 2015;Moore et al, 2013;Rapoport and Shaw, 2015;Rosa-Alc azar et al, 2015;S anchez-Meca et al, 2014;Thompson-Hollands et al, 2014;Watson and Rees, 2008). Treatment is offered on an individual or group basis to children with concurrent family sessions over about four months.…”

Section: Disorders Where Anxiety Is a Central Featurementioning

confidence: 99%

Family therapy and systemic interventions for child‐focused problems: the current evidence base

Carr

2018

Journal of Family Therapy

209

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This review updates previous similar papers published in JFT in 2000, 2009 and 2014. It presents evidence from meta‐analyses, systematic literature reviews, narrative literature reviews and controlled trials for the effectiveness of systemic interventions for families of children and adolescents with common mental health problems and other difficulties. In this context, systemic interventions include both family therapy and other family‐based approaches such as parent training, or parent implemented behavioural programmes. The evidence supports the effectiveness of systemic interventions either alone or as part of multimodal programmes for sleep, feeding and attachment problems in infancy; recovery from child abuse and neglect; conduct problems, emotional problems, eating disorders, somatic problems, and first episode psychosis.

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Section: Disorders Where Anxiety Is a Central Featurementioning

confidence: 99%

Family therapy and systemic interventions for child‐focused problems: the current evidence base

Carr

2018

Journal of Family Therapy

209

View full text Add to dashboard Cite

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“…The basal ganglia have long been considered mediators of OCD symptoms [ 43 ], and many neuroimaging studies have shown OCD-associated increases in the GM volume and metabolism/activation of the striatum [ 29 , 44–49 ]. Consistent with human findings [ 45 , 50 ], we found that SMB monkeys had larger caudate nuclei than control monkeys.…”

Section: Discussionmentioning

confidence: 99%

Rhesus monkeys exhibiting spontaneous ritualistic behaviors resembling obsessive-compulsive disorder

Zhai,

Tong,

et al. 2023

National Science Review

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Obsessive-compulsive disorder (OCD) is a chronic and debilitating psychiatric disorder that affects ∼2%–3% of the population globally. Studying spontaneous OCD-like behaviors in non-human primates may improve our understanding of the disorder. In large rhesus monkey colonies, we found 10 monkeys spontaneously exhibiting persistent sequential motor behaviors (SMBs) in individual-specific sequences that were repetitive, time-consuming and stable over prolonged periods. Genetic analysis revealed severely damaging mutations in genes associated with OCD risk in humans. Brain imaging showed that monkeys with SMBs had larger gray matter (GM) volumes in the left caudate nucleus and lower fractional anisotropy of the corpus callosum. The GM volume of the left caudate nucleus correlated positively with the daily duration of SMBs. Notably, exposure to a stressor (human presence) significantly increased SMBs. In addition, fluoxetine, a serotonergic medication commonly used for OCD, decreased SMBs in these monkeys. These findings provide a novel foundation for developing better understanding and treatment of OCD.

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“…OCD is a psychiatric disorder characterised specifically by periods of obsessions and/or compulsions, affecting 1–3% of children and adolescents. 5 Episodes can be relapsing and remitting, occurring throughout the entire lifespan. The clinical features include intrusive thoughts and impulses, causing distress to the individual and affecting daily functioning.…”

Section: Discussionmentioning

confidence: 99%

“…Children and adolescents were also affected socially owing to school closures. 5,9,10 The World Health Organization published guidance on hand hygiene, which was adopted and made the subject of a campaign in the UK as part of its guidance on infection prevention, along with advice on social distancing and mask use. [11][12][13] A recent paper described the changes in OCD phenomenology and presentation in the context of COVID-19.…”

Section: Overview Of Ocd and The Covid-19 Pandemicmentioning

confidence: 99%

Life-threatening obsessive–compulsive disorder precipitated by the COVID-19 pandemic in an adolescent

et al. 2022

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Summary The COVID-19 pandemic starting in 2020 has had massive mental health consequences worldwide. It has caused generalised fear and anxiety about catching, spreading and suffering from the virus. This article describes a fictionalised patient's presentation of life-threatening obsessive–compulsive disorder (OCD) associated with fears of catching COVID-19. The fears resulted in refusal to eat and drink, with subsequent weight loss that required paediatric admission. The scenario portrays the association between COVID-19 and life-threatening OCD symptoms and goes on to illustrate the patient's good response to standard OCD treatments.

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Obsessive compulsive disorder

Cited by 9 publications

References 147 publications

Family therapy and systemic interventions for child‐focused problems: the current evidence base

Family therapy and systemic interventions for child‐focused problems: the current evidence base

Rhesus monkeys exhibiting spontaneous ritualistic behaviors resembling obsessive-compulsive disorder

Life-threatening obsessive–compulsive disorder precipitated by the COVID-19 pandemic in an adolescent

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