Obsessive-Compulsive Disorder and Common Comorbidities

Brady, Charles F.

doi:10.4088/jcp.13023tx1c

Cited by 10 publications

(5 citation statements)

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“…Remarkably, OCD patients vary widely with respect to symptoms, age of illness onset, disease duration and comorbidities (Brady, 2014 ). Both selective serotonin reuptake inhibitors (SSRIs) and cognitive-behavioral therapy in OCD have also been linked to gray matter (GM) alternation (Szeszko et al, 2004 ; Huyser et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Brain Gray Matter Abnormalities in First-Episode, Treatment-Naive Children with Obsessive-Compulsive Disorder

Cheng

Cai

Wang

et al. 2016

Front. Behav. Neurosci.

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Although several magnetic resonance imaging (MRI) studies have been conducted in children with obsessive-compulsive disorder (OCD), the brain structural abnormalities in OCD, especially in children, are not yet well characterized. We aimed to identify gray matter (GM) abnormalities in the early stage of pediatric OCD and examine the relationship between these structural abnormalities with clinical characteristics. Examinations of 30 first-episode, treatment-naive pediatric OCD patients without any comorbidities and 30 matched healthy controls (HCs) were performed with 3.0 T magnetic resonance imaging (MRI). Voxel-based morphometry (VBM) following Diffeomorphic Anatomical Registration using Exponentiated Lie algebra (DARTEL) was used to conduct voxel-wise tests for group differences in regional gray matter volume (GMV). Compared to HCs, the patient group exhibited more GMV in the bilateral putamen and left orbitofrontal cortex (OFC) and less GMV in the left inferior parietal lobule (IPL). The GMV alternation in the right putamen of OCD patients was positively correlated with Hamilton Anxiety Rating Scale (HAM-A) scores, while the GMV alternation in the left IPL exhibited a trend to negatively correlate with HAM-A scores. Our current results suggest that the GM abnormalities were defined in the early stage of pediatric OCD. Moreover, these findings provided further evidence of brain GM abnormalities that are not only present in the classical fronto–striatal–thalamic circuit but also in the default mode network (DMN), which may represent the interaction of abnormally functional organization of both network in pediatric OCD.

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Section: Introductionmentioning

confidence: 99%

Brain Gray Matter Abnormalities in First-Episode, Treatment-Naive Children with Obsessive-Compulsive Disorder

Cheng

Cai

Wang

et al. 2016

Front. Behav. Neurosci.

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“…The reason for the generally lower prevalence of OCD in the population of Jönköping compared to the global population cannot easily be explained and further studies are needed on large groups. The comorbidities most often seen with OCD are additional psychiatric disorders [ 26 ].…”

Section: Resultsmentioning

confidence: 99%

Significant Association Between Obsessive-Compulsive Disorder And Atopic Dermatitis – A Retrospective Population-Based Case-Control Study

Åkerlund

Seifert

Assarsson

et al. 2023

Dermatol Pract Concept

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Introduction: Atopic dermatitis (AD) is a global health problem. There are no data on the association of AD with obsessive-compulsive disorder (OCD). Objectives: This study aimed to map a wide spectrum of different diseases among patients with atopic dermatitis compared to healthy controls in the Region of Jönköping County, Sweden with special focus on OCD. Methods: We conducted a retrospective case control study from January 1st 2013 until December 31st 2021 using an electronic medical records database covering the entire population of the County of Jönköping. ICD-10 codes were used to identify patients with AD. Individuals without AD served as controls. A total number of 398,874 citizens under the age of 90 was included in this study and among these 2,946 individuals were diagnosed with AD. Regression analysis was performed to describe the risk for comorbidities in patients with AD compared to controls, adjusted for age and gender. Results: We found an association between obsessive-compulsive disorder (OCD) in patients with AD (adjusted odd ratio 2.0, 95% confidence interval 1.5-2.7, p<0.001). Other results are in the line with other studies. Conclusion: Pointing to previous studies, the cause of AD and OCD share several gene-environmental mechanisms and this association should be further studied on larger populations. The results of the present study underline the need for dermatologists to be aware of OCD and to screen for this condition in AD patients because early diagnosis and treatment may improve outcome.

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“…Voiding dysfunction in OCD patients may be caused by undiagnosed neurological disorders, Huntington's disease, dementia, or neurodegenerative conditions are examples of neurological disorders that can cause OCD. [24][25][26][27] Ambulatory urodynamic monitoring is recommended when the severity of the patient's symptoms does not correlate with conventional urodynamic findings. Ambulatory urodynamic monitoring, according to Rademakers et al, 24 provides more accurate results than conventional urodynamic monitoring.…”

Section: Discussionmentioning

confidence: 99%

“…It is important to note that certain obsessions in OCD patients may have neurological as well as mental origins. Voiding dysfunction in OCD patients may be caused by undiagnosed neurological disorders, Huntington's disease, dementia, or neurodegenerative conditions are examples of neurological disorders that can cause OCD 24–27 . Ambulatory urodynamic monitoring is recommended when the severity of the patient's symptoms does not correlate with conventional urodynamic findings.…”

Section: Discussionmentioning

confidence: 99%

Association between lower urinary tract symptoms (LUTS) and obsessive‐compulsive disorders (OCD) in women: A study based on urodynamic findings and micturition problem

Rezaeimehr

Zargham

Jahanabadi

et al. 2021

Neurourology and Urodynamics

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This study focused on women with chronic lower urinary tract symptoms (LUTS) who simultaneously suffered from obsessive-compulsive disorder (OCD) to evaluate the association between micturition abnormality and OCD.Methods: A cohort case study was conducted on 128 women with chronic LUTS who visited the academic clinic from 2012 to 2018. The participants with a history of OCD were grouped together, whereas the other group consisted of those with no psychiatric issues. Data were analyzed using the Kolmogorov-Smirnov test and also the nonparametric Kruskal-Wallis and χ 2 tests. Results:The participants with OCD had a lower mean age (41.7 vs. 48.8 years) and longer symptom duration than the control group. Moreover, voiding phase problems were more prevalent among OCD patients (mean voiding score: 9.3 vs. 6.9). Urge urinary incontinence (UUI) was the most common type of urinary incontinence in OCD patients, and the most important urodynamic study finding was bladder outlet obstruction (45% and 17% in the OCD and control groups, respectively). Voiding disorders resulted in chronic renal failure in two patients (3.12%). It was shown that bladder outlet obstruction (odds ratio (OR) 4.43, 95% confidence interval [CI] 1.53-12.78, p = 0.006] was the strongest predictor of OCD and stress urinary incontinence (OR 0.20, 95% CI 0.07-0.53, p < 0.001) was the best protector against OCD. Conclusion:The findings revealed that chronic LUTS was related to voiding dysfunction and urodynamic abnormality in OCD patients. These disorders may be categorized as somatoform disorder that requires appropriate treatments.

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Obsessive-Compulsive Disorder and Common Comorbidities

Cited by 10 publications

References 0 publications

Brain Gray Matter Abnormalities in First-Episode, Treatment-Naive Children with Obsessive-Compulsive Disorder

Brain Gray Matter Abnormalities in First-Episode, Treatment-Naive Children with Obsessive-Compulsive Disorder

Significant Association Between Obsessive-Compulsive Disorder And Atopic Dermatitis – A Retrospective Population-Based Case-Control Study

Association between lower urinary tract symptoms (LUTS) and obsessive‐compulsive disorders (OCD) in women: A study based on urodynamic findings and micturition problem

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