Obsessive-compulsive disorder and head trauma: A rare association

Jenike, Michael A.; Brandon, Allen D.

doi:10.1016/0887-6185(88)90030-8

Cited by 16 publications

(6 citation statements)

References 4 publications

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“…We could not fi nd studies approaching incidence of OCD after TBI in a more strict defi nition. However, there are several case reports and series richly described in literature, giving some evidence for a traumatic etiology in some cases (McKeon et al 1984;Jenike and Brandon 1988;Kant et al 1996;Childers et al 1998;Bilgic et al 2004;Ogai et al 2005).…”

Section: Obsessive-compulsive Disorder Diagnosis and Epidemiologymentioning

confidence: 99%

Psychiatric disorders and traumatic brain injury

Schwarzbold¹,

Diaz²,

Martins

et al. 2008

NDT

101

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Psychiatric disorders after traumatic brain injury (TBI) are frequent. Researches in this area are important for the patients' care and they may provide hints for the comprehension of primary psychiatric disorders. Here we approach epidemiology, diagnosis, associated factors and treatment of the main psychiatric disorders after TBI. Finally, the present situation of the knowledge in this fi eld is discussed.

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Section: Obsessive-compulsive Disorder Diagnosis and Epidemiologymentioning

confidence: 99%

Psychiatric disorders and traumatic brain injury

Schwarzbold¹,

Diaz²,

Martins

et al. 2008

NDT

101

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“…In 1968 Lishman conducted an extensive review of psychiatric sequelae of brain damage and reported two cases of 'obsessivecompulsive disorder' from 144 brain-damaged patients with severe psychiatric disability (Lishman, 1968). In accord with the low rates of OCD post-TBI observed by Lishman (1968), Jenike and Brandom (1984) reported on the 'rare association ' TBI and OCD and McKeon et al (1984) reported on four cases of OCD post-TBI. McKeon's series includes adults whose OCD symptoms started 'within 24 hours of a head injury ' (McKeon et al, 1984) One of the patients had a monozygotic twin with no signs of obsessive-compulsive illness and another had a pre-morbid 'mildly obsessional' personality.…”

Section: Obsessive-compulsive Disorder and Obsessive-compulsive Symptmentioning

confidence: 80%

Obsessive-compulsive disorder after traumatic brain injury

Grados

2003

International Review of Psychiatry

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Traumatic brain injury ( TBI) neuropsychiatric sequelae are a significant cause of morbidity in TBI victims. Among the recognized sequelae are anxiety, obsessions, compulsions and obsessive-compulsive disorder (OCD). This review addresses the emergence of OCD and OCD symptoms after TBI with an emphasis on neural circuits that underlie OCD symptom expression that may be affected by the injury. Current studies suggest that post-TBI emergent psychopathology, including OCD, is influenced by underlying sub-clinical diathesis, brain injury lesions sites, environmental stressors and the rehabilitation process. Pre-morbid status can be obtained by structured psychiatric interviews, and TBI brain lesions can be defined with advanced neuroimaging techniques. This information along with the management of family and environmental stressors and the enhanced clinical identification of symptoms of anxiety and OCD can be used in the rehabilitation process to improve prognosis after TBI.

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“…Subsequently, other disorders that also affect the basal ganglia were found to be associated with OCD. These disorders were of diverse origin and included the G illes de la Tourette syndrome (Pauls et al, 1986), frontal lobe m eningioma (Seibyl et al, 1989), Sydenham' s chorea (Swedo et al, 1989a), bilateral circumscribed pallidostiatal necrosis (Laplane, 1981), basal ganglia changes after carbon m onoxide poisoning, anoxia during anesthesia or heart attack, and consequences of intoxication with disul® ram (Laplane, 1989), cingulate (Levin & Duchowny, 1991) and tem poral lobe epilepsy (Kroll & Drummond, 1993), as well as head trauma (Jenike, 1988). Stimu lation of the anterior cingulate in humans also provoked compulsion-like behavior (Talairach et al, 1973).…”

Section: Brain Pathology and Oc Dmentioning

confidence: 97%

“…Therefore, OCD cannot be sim ply a faulty functional expression of activity in a dysfunctional loop that can be corrected by interruption in its circuitry. Furtherm ore, m any patients with OCD exhibit no neurological abnormalities (Thomsen & Jensen, 1991) and OCD as consequence of brain trauma is rare (Jenike, 1988). Obsessive± compulsive disorder most likely is a heterogeneous and m ultifactorial disorder.…”

Section: Brain Pathology and Oc Dmentioning

confidence: 99%

Psychobiology of obsessive-compulsive disorder: anatomical and physiological considerations

Hoehn‐Saric

Greenberg²

1997

International Review of Psychiatry

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Sum m arySeveral models seek to explain the psych obiology of obsessive± com pulsiv e disorder (O CD). W hile none fully explains brain m ech anism s responsible for the psychopathology of OC D, such models, based on clinical and experimenta l studies, elucid ate further direction . This article review s evidence from clinica l observations and from electrophysiological and im aging stud ies on which the models were based. A variety of neurolo gica l diseases that involv e the fronto± striatal and lim bic/paralim bic system s are associated with obsessive and com pulsive sym ptom s. E lectroph ysiological and im aging studies in O CD patients free from dem onstra ble neurolo gical lesions, strongly suggest that these regions are involved in the pathobiology of obsessive± com pulsive disorder. The m ost consiste nt ® ndings in im aging stud ies were increased m eta bolism and blood¯ow in orbito± frontal regions at rest and, in addition, regional changes in the striatum and in lim bic/paralim bic regions during sym ptom provocation . Imaging studies indicate predomina nt prefrontal hyperactiv ity, particularly on the right. Neuroim aging, electrophysiological and neuropsychological stud ies suggest that both hem ispheres may contribute, perhaps to different degrees, to the pathophysiology of OC D. Since OC D is a heterogen eous disorder, it is likely that regionally speci® c pathology in the disorder will be variable.

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Obsessive-compulsive disorder and head trauma: A rare association

Cited by 16 publications

References 4 publications

Psychiatric disorders and traumatic brain injury

Psychiatric disorders and traumatic brain injury

Obsessive-compulsive disorder after traumatic brain injury

Psychobiology of obsessive-compulsive disorder: anatomical and physiological considerations

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