Obsessive–Compulsive Disorder

Bokor, Gyula; Anderson, Peter

doi:10.1177/0897190014521996

Cited by 63 publications

(52 citation statements)

References 151 publications

(183 reference statements)

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“…OCD is a common heterogeneous psychiatric disorder that is characterized by obsessions and compulsions 124,125 . Obsessions are intrusive, recurrent and persistent unwanted thoughts, and are often associated with elevated anxiety 124,125 .…”

Section: Self-grooming In Cns Disordersmentioning

confidence: 99%

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Neurobiology of rodent self-grooming and its value for translational neuroscience

Stewart²,

et al. 2015

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Self-grooming is a complex innate behaviour with an evolutionary conserved sequencing pattern and is one of the most frequently performed behavioural activities in rodents. In this Review, we discuss the neurobiology of rodent self-grooming, and we highlight studies of rodent models of neuropsychiatric disorders — including models of autism spectrum disorder and obsessive compulsive disorder — that have assessed self-grooming phenotypes. We suggest that rodent self-grooming may be a useful measure of repetitive behaviour in such models, and therefore of value to translational psychiatry. Assessment of rodent self-grooming may also be useful for understanding the neural circuits that are involved in complex sequential patterns of action.

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Section: Self-grooming In Cns Disordersmentioning

confidence: 99%

“…Obsessions are intrusive, recurrent and persistent unwanted thoughts, and are often associated with elevated anxiety 124,125 . Compulsions include a range of repetitive behaviours or thoughts.…”

Section: Self-grooming In Cns Disordersmentioning

confidence: 99%

Neurobiology of rodent self-grooming and its value for translational neuroscience

Stewart²,

et al. 2015

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“…4) The consensus is that the neural circuits for OCD and anxiety differ (Burguiere et al 2015, Hoffman 2011. Neurotransmitters underlying OCD are the monoamines, mostly serotonin and, likely, glutamate (Bokor andAnderson 2014, Egashira et al 2008). GABA remains the primary transmitter thought to underlie most anxieties.…”

Section: Introductionmentioning

confidence: 99%

Marble burying as compulsive behaviors in male and female mice

Taylor¹,

Lerch²,

Chourbaji³

2017

Acta Neurobiologiae Experimentalis

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Marble burying is considered an, albeit controversial, animal model of the compulsive like behaviors of obsessive-compulsive disorder (OCD). Hallmark features of OCD patients are similarities and, more prominent, differences from anxiety disorders, e.g., the absence of sex differences and resistance to spontaneous remission. We report an experiment on marble burying by male and female C57/BL6/N mice. Animals were administered either the classic anxiolytic drug, diazepam, that targets the GABA receptor or a "pure" inhibitor of the serotonin transporter, escitalopram, that has been reported to be particularly effective in OCD. A burying paradigm that more precisely mimics the human condition was used, e.g., testing in the home environment, chronic drug exposure and acknowledging individual differences by pre-selecting for high marble burying. Results were that there were no sex differences in groups treated with drugs or in control mice. Both diazepam and escitalopram decreased numbers of marbles buried compared to vehicle-only controls in the absence of correlated changes in anxiety. Diazepam, however, was more effective than escitalopram in suppressing MB. The conclusion is that along with serotonin, GABA is involved in regulating compulsive behaviors. The marble burying paradigm may prove more useful for pharmacological drugs tests of impulsivity or attention deficit because of the involvement of serotonin and GABA in both disorders.

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“…Clinical evidence and molecular imaging studies support the involvement of dopamine in OCD. Atypical antipsychotics and dopaminergic agents can reduce or exacerbate OCD symptoms, respectively (Bokor and Anderson, 2014). The few reports on DA receptor binding in OCD consistently show decreased DA receptor availability (Denys et al, 2013, Perani et al, 2008 supporting the hypothesis of chronically increased dopaminergic activity in the disorder, which has been recently observed in different brain regions including left and right cerebellum of OCD patients (Hsieh et al, 2014).…”

Section: Discussionmentioning

confidence: 97%