Obsessive-Compulsive Symptoms and Positive, Negative, and Depressive Symptoms in Patients with Recent-Onset Schizophrenic Disorders

Abstract

Obsessive-compulsive symptoms and positive, negative, and depressive symptoms in patients with recent-onset schizophrenic disorders de Haan, L.; Hoogenboom, B.; Beuk, N.; van Amelsvoort, T.; Linszen, D.H. Published in:Canadian Journal of Psychiatry Link to publication Citation for published version (APA):de Haan, L., Hoogenboom, B., Beuk, N., van Amelsvoort, T., & Linszen, D. H. (2005). Obsessive-compulsive symptoms and positive, negative, and depressive symptoms in patients with recent-onset schizophrenic disorders. Canadian Journal of Psychiatry, 50(9), 519-524. General rightsIt is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. Objectives: To study the relation between obsessive-compulsive symptoms (OCS) and positive, negative, and depressive symptoms in patients with recent-onset schizophrenic disorders. Methods:We undertook a prospective study of 113 consecutively hospitalized patients with recent-onset schizophrenia or related disorders diagnosed according to DSM-IV criteria. We compared 3 subgroups: one without comorbid OCS, one with OCS not fulfilling DSM-IV criteria for obsessive-compulsive disorder (OCD), and one with comorbid OCD diagnosed according to DSM-IV criteria. We assessed OCS severity at admission and 6 weeks thereafter with the Yale-Brown Obsessive Compulsive Scale (Y-BOCS). The Positive and Negative Syndrome Scale (PANSS) and the Montgomery-Asberg Depression Rating Scale (MADRS) were independently administered. Results:At admission, patients with schizophrenic disorders and OCD had higher mean MADRS scores than both other groups; patients with OCS not fulfilling DSM-IV criteria for OCD had lower mean PANSS negative subscale scores than both other groups. After 6 weeks, there were no significant between-group differences, and OCS severity remained constant. Conclusions:Acute patients with recent-onset schizophrenia and OCD have more severe depressive symptoms but do differ in negative symptoms, compared with patients without comorbid OCD. Mild OCS may be related to less severe negative symptoms. During regular inpatient treatment, OCS severity remains constant.(Can J Psychiatry 2005;50:519-524)Information on funding and support and author affiliations appears at the end of the article.Clinical Implications · Acute patients with recent-onset schizophrenia and OCD...

Neurological Soft Signs in Schizophrenia Patients With Obsessive-Compulsive Disorder

“…2,3 The validity of the schizophrenia-OCD association is also supported by the outcome differences in schizophrenia patients with and without OCD, with schizo-obsessive individuals having poorer prognoses, greater impairment in functioning, and treatment resistance. [4][5][6] Schizophrenia and OCD are considered to be neurodevelopmental disorders with structural and functional brain abnormalities in the prefrontal cortex, striatum, and thalamus being consistently implicated in both disorders.…”

Lamotrigine augmentation in schizophrenia and schizoaffective patients with obsessive-compulsive symptoms

“…A similar rate of OCD (approximately 20%) was found in adolescent, adult and elderly schizophrenia patients underscoring its clinical significance across the life span (Nechmad, et al, 2003;Poyurovsky, et al, 2006). Moreover, a substantial rate of OCD was found in firstepisode, drug-naive schizophrenia patients, indicating that OCD in schizophrenia is not only a direct consequence of chronic course of illness or antipsychotic treatment (Poyurovsky, et al, 1999;de Haan, et al, 2005). The validity of the schizo-obsessive subgroup is further supported by a distinct pattern of familial inheritance, neuro-cognitive deficits and pharmacotherapy, as well as by a poorer course and prognosis compared with non-OCD schizophrenia patients (Fenton and McGlashan, 1986;Green, et al, 2003;Poyurovsky, et al, 2005a).…”

Relevance of Five-Factor Model personality traits for obsessive–compulsive symptoms in patients with psychotic disorders and their un-affected siblings

“…In addition, to control for the potential confounding effect of depression, which is associated with both comorbid OCS (de Haan et al, 2005;Lysaker and Whitney, 2009), and FFM personality traits (Ormel et al, 2004a), we excluded patients and siblings if DSM-IV criteria for a current major depressive episode were fulfilled (patients n¼51, siblings n¼33). We chose not to integrate a dimensional measure of depression severity as a covariate, because these measures cannot clearly differentiate between clinical depression (MDE) and nonspecific negative affectivity.…”