Obsessive–compulsive symptoms interact with disorganization in influencing social functioning in schizophrenia

Tonna, Matteo; Ottoni, Rebecca; Paglia, Francesca; Ossola, Paolo; Panfilis, Chiara De; Marchesi, Carlo

doi:10.1016/j.schres.2016.01.002

Cited by 20 publications

(14 citation statements)

References 33 publications

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“…73 The rsFC between the left fusiform gyrus and the medial oFG correlated inversely with Y-BOCS compulsive behavior subscale scores in patients with SOC, suggesting that obsessive behavior may be a reflection of neural adaptation, ie, a compensatory effect in patients with SOC. 17 A similar mechanism has been found in generalized anxiety disorder and PTSD patients. 74 Another important observation in this study is that patients with SOC exhibited significantly decreased rsFC between the DMN and the SN, particularly between DMN subregions and the SMA.…”

Section: Discussionsupporting

confidence: 54%

“…12 One study has reported a dual impact of OCD on functioning in SCZ with a gradual transition from an improving to a worsening effect depending on OCD symptoms severity. 17 Neuroimaging findings have shown that patients with SOC could have smaller whole brain gray matter volume, 18 smaller hippocampal volume, 19 and enlarged anterior horn of the lateral ventricles. 20 These results support the "double jeopardy hypothesis" of SOC.…”

Section: Introductionmentioning

confidence: 99%

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Altered Functional Connectivity of the Default Mode Network in Patients With Schizo-obsessive Comorbidity: A Comparison Between Schizophrenia and Obsessive-compulsive Disorder

Wang

Zou

Xie

et al. 2018

Schizophrenia Bulletin

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Clinical and neuroimaging data support the idea that schizo-obsessive comorbidity (SOC), similar to obsessive-compulsive disorder (OCD) and schizophrenia (SCZ), may be a distinct brain disorder. In this study, we examined the strength of resting-state functional connectivity (rsFC) between 19 subregions of the default mode network (DMN) and whole brain voxels in 22 patients with SOC features, 20 patients with SCZ alone, 22 patients with OCD, and 22 healthy controls (HC). The main results demonstrated that patients with SOC exhibited the highest rsFC strength within subregions of the DMN and the lowest rsFC strength between the DMN and subregions of the salience network (SN) compared with the other 3 groups. In addition, compared with HCs, all 3 patient groups exhibited increased rsFC between subregions of the DMN and the executive control network (ECN). The SOC and SCZ group both exhibited increased rsFC between subregions of the DMN and the middle temporal gyrus, but the OCD group exhibited decreased rsFC between them. These findings highlight a specific alteration in functional connectivity in the DMN in patients with SOC, and provide new insights into the dysfunctional brain organization of different mental disorders.

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Section: Discussionsupporting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Altered Functional Connectivity of the Default Mode Network in Patients With Schizo-obsessive Comorbidity: A Comparison Between Schizophrenia and Obsessive-compulsive Disorder

Wang

Zou

Xie

et al. 2018

Schizophrenia Bulletin

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“…Due to the close relationship between obsessive–compulsive symptoms and schizophrenia, a previous study regarded obsessive–compulsive symptoms as a buffer that may help to prevent the emergence of psychosis during the prodromal period (Pious, 1950). Recent studies have speculated that specific obsessive themes may confer a certain functional order and stability that counterbalances the functional impairment caused by the underlying thought and behavioral disorganization process (Tonna, Ottoni, Paglia, Monici, et al, 2016; Tonna, Ottoni, Paglia, Ossola, et al, 2016). Meanwhile, there is also an overlap between delusional and obsessive phenomena, causing difficulties in identifying obsessive–compulsive symptoms (Tezenas du Montcel, Pelissolo, Schurhoff, & Pignon, 2019).…”

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confidence: 99%

Schizotypal and obsessive–compulsive traits: Co‐occurrence rate and relationship with executive function, emotion experience, and emotion expressivity in college students

et al. 2020

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Empirical findings suggest that there is an overlap between schizophrenia and obsessive-compulsive disorder (OCD). These disorders also have a high comorbidity rate. However, little is known about the impact of co-occurring schizotypal and obsessive-compulsive traits on executive function, emotion experience, and emotion expressivity in the normal population. The present study examined the prevalence of coexisting schizotypal and obsessive-compulsive traits and the relationship between these two traits in a sample of healthy college students. We also conducted a moderation analysis to explore the effect of these two type of traits on executive function, emotion experience, and emotion expressivity. We recruited 3,319 participants to complete the Schizotypal Personality Questionnaire (SPQ) and the Obsessive-Compulsive Inventory-Revised (OCI-R). A subset of them (n = 575) also completed the Chinese versions of the Dysexecutive Questionnaire (DEX), the Temporal Experience of Pleasure Scale (TEPS), and the Emotional Expressivity Scale (EES). We found that the prevalence of co-occurring schizotypal and OCD traits was 3.33%. All the subscales of the SPQ and the OCI-R significantly correlated with each other. Both traits had a negative impact on executive function and emotion expressivity. The interaction between the disorganization dimension of schizotypal traits and OCD traits had a significant effect on executive function, but not emotion experience or emotion expressivity. This study was limited by its cross-sectional design and recruitment of only college students. These findings suggest that there is an approximately 3% rate of co-occurring schizotypal and obsessive-compulsive traits in a healthy college student sample. The interaction between these two types of traits may influence executive function.

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“…Diagnostic criteria for a schizo-obsessive subgroup of schizophrenia has been proposed [47], and a reverse U-shaped curve between the obsessive-compulsive dimension and functioning in schizophrenia patients might model this relationship [48]. Nevertheless, the disorganization dimension appears to be the most relevant dimension, moderating this complex psychopathological observation [49].…”

Section: Discussionmentioning

confidence: 99%

Cenesthopathy and Subjective Cognitive Complaints: An Exploratory Study in Schizophrenia

Bulnes

Aragón

2018

Psychopathology

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Background/Aims: Cenesthopathy is mainly associated with schizophrenia; however, its neurobiological basis is nowadays unclear. The general objective was to explore clinical correlates of cenesthopathy and subjective cognitive complaints in schizophrenia. Methods: Participants (n = 30) meeting DSM-IV criteria for psychotic disorder were recruited from a psychiatry unit and assessed with: Association for Methodology and Documentation in Psychiatry (AMDP) system, Positive and Negative Syndrome Scale, Frankfurt Complaint Questionnaire (FCQ), and the Bonn Scale for the Assessment of Basic Symptoms (BSABS). For quantitative variables, means and Spearman correlation coefficients were calculated. Linear regression following backward method and principal component analysis with varimax rotation were used. Results: 83.3% of subjects (73.3% male, mean age, 31.5 years) presented any type of cenesthopathy; all types of cenesthetic basic symptoms were found. Cenesthetic basic symptoms significantly correlated with the AMDP category “fear and anancasm,” FCQ total score, and BSABS cognitive thought disturbances. In the regression analysis only 1 predictor, cognitive thought disturbances, entered the model. In the principal component analysis, a main component which accounted for 22.69% of the variance was found. Conclusions: Cenesthopathy, as assessed with the Bonn Scale (BSABS), is mainly associated with cognitive abnormalities including disturbances of thought initiative and mental intentionality, of receptive speech, and subjective retardation or pressure of thoughts.

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Obsessive–compulsive symptoms interact with disorganization in influencing social functioning in schizophrenia

Abstract: Data suggest that in patients with schizophrenia, functioning at least in part depends on the interaction between disorganization and OCS.

Cited by 20 publications

References 33 publications

Altered Functional Connectivity of the Default Mode Network in Patients With Schizo-obsessive Comorbidity: A Comparison Between Schizophrenia and Obsessive-compulsive Disorder

Altered Functional Connectivity of the Default Mode Network in Patients With Schizo-obsessive Comorbidity: A Comparison Between Schizophrenia and Obsessive-compulsive Disorder

Schizotypal and obsessive–compulsive traits: Co‐occurrence rate and relationship with executive function, emotion experience, and emotion expressivity in college students

Cenesthopathy and Subjective Cognitive Complaints: An Exploratory Study in Schizophrenia

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