Obstacle–Avoidance robots have become an essential field of study in recent years. This paper analyzes two cases that extend reactive systems focused on obstacle detection and its avoidance. The scenarios explored get data from their environments through sensors and generate information for the models based on artificial intelligence to obtain a reactive decision. The main contribution is focused on the discussion of aspects that allow for comparing both approaches, such as the heuristic approach implemented, requirements, restrictions, response time, and performance. The first case presents a mobile robot that applies a fuzzy inference system (FIS) to achieve soft turning basing its decision on depth image information. The second case introduces a mobile robot based on a multilayer perceptron (MLP) architecture, which is a class of feedforward artificial neural network (ANN), and ultrasonic sensors to decide how to move in an uncontrolled environment. The analysis of both options offers perspectives to choose between reactive Obstacle–Avoidance systems based on ultrasonic or Kinect sensors, models that infer optimal decisions applying fuzzy logic or artificial neural networks, with key elements and methods to design mobile robots with wheels. Therefore, we show how AI or Fuzzy Logic techniques allow us to design mobile robots that learn from their “experience” by making them safe and adjustable for new tasks, unlike traditional robots that use large programs to perform a specific task.