Obstacle circumvention and eye coordination during walking to least and most affected side in people with Parkinson’s disease

Barbieri, Fábio Augusto; Polastri, Paula Fávaro; Gobbi, Lilian Teresa Bucken; Simieli, Lucas; Pereira, Vinicius Ignácio Alota; Baptista, André Macari; Moretto, Gabriel Felipe; Fiorelli, Carolina Menezes; Imaizumi, Luis Felipe Itikawa; Rodrigues, Sérgio Tosi

doi:10.1016/j.bbr.2017.11.032

Cited by 9 publications

(3 citation statements)

References 66 publications

(94 reference statements)

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“…The PwPD were assessed in the “ON” state of Parkinson’s disease medication. To determine the lower-limb preference of the CG, the participants were asked to kick a ball, with the limb used to kick considered as the preferred ( Barbieri et al, 2018a , b ). For the PwPD, the most affected limb was determined through items 20–23 and 25–26 of UPDRS-III.…”

Section: Methodsmentioning

confidence: 99%

“…Gait initiation (GI) difficulties ( Delval et al, 2014 ) and gait asymmetry ( Barbieri et al, 2018a , b ; Orcioli-Silva et al, 2020 ) are among the most incapacitating symptoms present in Parkinson’s disease. GI difficulties result from slower and smaller center of pressure (CoP) movement, which is influenced by reduced production of medial-lateral and anterior–posterior force ( Rogers et al, 2011 ; Delval et al, 2014 ; Boonstra et al, 2016 ) (Simieli, 2021, under review) 1 , resulting in a shortened first step when initiating gait in people with Parkinson’s disease (PwPD; Simieli, 2021, under review, see footnote 1).…”

Section: Introductionmentioning

confidence: 99%

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(A)symmetry during gait initiation in people with Parkinson’s disease: A motor and cortical activity exploratory study

Faria

Simieli

Rietdyk

et al. 2023

Front. Aging Neurosci.

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BackgroundGait asymmetry and deficits in gait initiation (GI) are among the most disabling symptoms in people with Parkinson’s disease (PwPD). Understanding if PwPD with reduced asymmetry during GI have higher asymmetry in cortical activity may provide support for an adaptive mechanism to improve GI, particularly in the presence of an obstacle.ObjectiveThis study quantified the asymmetry of anticipatory postural adjustments (APAs), stepping parameters and cortical activity during GI, and tested if the presence of an obstacle regulates asymmetry in PwPD.MethodsSixteen PwPD and 16 control group (CG) performed 20-trials in two conditions: unobstructed and obstructed GI with right and left limbs. We measured, through symmetry index, (i) motor parameters: APAs and stepping, and (ii) cortical activity: the PSD of the frontal, sensorimotor and occipital areas during APA, STEP-I (moment of heel-off of the leading foot in the GI until the heel contact of the same foot); and STEP-II (moment of the heel-off of the trailing foot in the GI until the heel contact of the same foot) phases.ResultsParkinson’s disease showed higher asymmetry in cortical activity during APA, STEP-I and STEP-II phases and step velocity (STEP-II phase) during unobstructed GI than CG. However, unexpectedly, PwPD reduced the level of asymmetry of anterior–posterior displacement (p < 0.01) and medial-lateral velocity (p < 0.05) of the APAs. Also, when an obstacle was in place, PwPD showed higher APAs asymmetry (medial-lateral velocity: p < 0.002), with reduced and increased asymmetry of the cortical activity during APA and STEP-I phases, respectively.ConclusionParkinson’s disease were not motor asymmetric during GI, indicating that higher cortical activity asymmetry can be interpreted as an adaptive behavior to reduce motor asymmetry. In addition, the presence of obstacle did not regulate motor asymmetry during GI in PwPD.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

(A)symmetry during gait initiation in people with Parkinson’s disease: A motor and cortical activity exploratory study

Faria

Simieli

Rietdyk

et al. 2023

Front. Aging Neurosci.

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“…), location and motion characteristics (providing information on speed and direction), which are essential for successful obstacle circumvention. [7][8][9][10][11][12][13] Individuals continuously update information about the obstacle and compute the affordances of passable paths, adjusting their trajectory, timing and speed to maintain a safe distance from the obstacle based on the real-time perception of a theoretical point of collision (TPC). [14,15] For instance, in a normal obstacle circumvention, individuals are expected to initiate the maneuver at least 1 meter away from the obstacle, [4] deviate laterally at a distance necessary to ensure clearance [5] and adjust their walking speed to adjust to spatial and temporal properties of the obstacle.…”

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confidence: 99%

Exploring the challenges of avoiding collisions with virtual pedestrians using a dual-task paradigm in individuals with chronic moderate to severe traumatic brain injury

Sousa,

Gagnon,

et al. 2024

Preprint

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Background: Individuals with a moderate-to-severe traumatic brain injury (m/sTBI), despite good locomotor recovery after six months post-injury, face challenges in adapting locomotion to the environment. They also present with altered cognitive functions, which may impact dual-task walking abilities. Whether they present collision avoidance strategies with moving pedestrians that are altered under dual-task conditions, however, remains unclear. This study aimed to compare between individuals with m/sTBI and age-matched control individuals: (1), the locomotor and cognitive costs associated with the concurrent performance of circumventing approaching virtual pedestrians (VRPs) while attending to an auditory-based cognitive task and; (2) gaze behaviours associated with VRP circumvention task between single and dual-task conditions. Methodology: Twelve individuals with m/sTBI (age=43.3±9.5 yrs; >6 mo. post injury) and 12 healthy controls (CTLs) (age=41.8±8.3 yrs) were assessed while walking in a virtual subway station viewed in a head-mounted display. They performed a collision avoidance task with VRPs, as well as auditory-based cognitive tasks (pitch discrimination and auditory Stroop), both under single and dual-task conditions. Dual-task cost (DTC) for onset distance of trajectory deviation, minimum distance from the VRP, maximum lateral deviation, walking speed, gaze fixations and cognitive task accuracy were contrasted between groups using generalized estimating equations. Results: In contrast to CTLs who showed locomotor DTCs only, individuals with m/sTBI displayed both locomotor and cognitive DTCs. While both groups walked slower under dual-task conditions, only individuals with m/sTBI failed to modify their onset distance of trajectory deviation and maintained smaller minimum distances and smaller maximum lateral deviation compared to single-task walking. Both groups showed shorter gaze fixations on the approaching VRP under dual-task conditions, but this reduction was less pronounced in the individuals with m/sTBI. A reduction in cognitive task accuracy under dual-task conditions was found in the m/sTBI group only. Conclusion: Individuals with m/sTBI present altered locomotor and gaze behaviours as well as cognitive performances when executing a collision avoidance task involving moving pedestrians, especially under dual-task conditions. Potential mechanisms explaining those alterations are discussed. Present findings highlight the compromised complex walking abilities in individuals with m/sTBI who otherwise present a good locomotor recovery.

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Influence of obstacle color on locomotor and gaze behaviors during obstacle avoidance in people with Parkinson’s disease

et al. 2018

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Obstacle circumvention and eye coordination during walking to least and most affected side in people with Parkinson’s disease

Abstract: The obstacle circumvention to the most affected side is risky for people with PD.

Cited by 9 publications

References 66 publications

(A)symmetry during gait initiation in people with Parkinson’s disease: A motor and cortical activity exploratory study

(A)symmetry during gait initiation in people with Parkinson’s disease: A motor and cortical activity exploratory study

Exploring the challenges of avoiding collisions with virtual pedestrians using a dual-task paradigm in individuals with chronic moderate to severe traumatic brain injury

Influence of obstacle color on locomotor and gaze behaviors during obstacle avoidance in people with Parkinson’s disease

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