Obstetric and neonatal complications in pregnancies conceived after oocyte donation: a systematic review and meta‐analysis

Storgaard, M.; Loft, Anne; Bergh, Christina; Wennerholm, Ulla‐Britt; Söderström‐Anttila, Viveca; Romundstad, Liv Bente; Aittomäki, Kristiina; Oldereid, Nan Birgitte; Forman, Julie Lyng; Pinborg, Anja

doi:10.1111/1471-0528.14257

Cited by 140 publications

(88 citation statements)

References 51 publications

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“…Five meta-analyses on pregnancy complications and perinatal outcomes after OD cycles are available in the literature [151–155]. Unfortunately, these meta-analytic data were obtained without any adjustment for confounders and including studies with very high risk of biases.…”

Section: Resultsmentioning

confidence: 99%

“…Finally, the last systematic review with meta-analysis [155] included, after search for original studies reporting at least five OD pregnancies with a control group of pregnancies conceived by conventional IVF/ICSI or NC and case series with > 500 cases, 35 studies reporting one or more pregnancy and perinatal complications were analyzed. The risk of PIH (aOR 2.30, 95 % CI 1.60 to 3.32), PE (aOR 2.11, 95 % CI 1.42 to 3.15), LBW (aOR 1.53, 95 % CI 1.16 to 2.01), PTB (aOR 1.75, 95 % CI 1.39 to 2.20) and CS (aORs 2.20, 95 % CI 1.85 to 2.60) was higher in OD than in IVF singleton pregnancies, whereas in multiple pregnancies only the incidence of PIH (aOR 2.45, 95 % CI 1.53 to 3.93) and PE (aOR 3.31, 95 % CI 1.61 to 6.80) was increased [155].…”

Section: Resultsmentioning

confidence: 99%

“…The risk of PIH (aOR 2.30, 95 % CI 1.60 to 3.32), PE (aOR 2.11, 95 % CI 1.42 to 3.15), LBW (aOR 1.53, 95 % CI 1.16 to 2.01), PTB (aOR 1.75, 95 % CI 1.39 to 2.20) and CS (aORs 2.20, 95 % CI 1.85 to 2.60) was higher in OD than in IVF singleton pregnancies, whereas in multiple pregnancies only the incidence of PIH (aOR 2.45, 95 % CI 1.53 to 3.93) and PE (aOR 3.31, 95 % CI 1.61 to 6.80) was increased [155]. The risk of PE (aOR 2.94, 95 % CI 2.29 to 3.76), PTB (aOR 2.30, 95 % CI 1.09 to 4.87), LBW (aOR 1.94, 95 % CI 1.10 to 3.41) and CS (aOR 2.38, 95 % CI 2.01 to 2.81) was also increased in OD vs. NC singleton pregnancies [155]. Postpartum hemorrhage resulted increased in OD vs. IVF both in singleton (aOR 2.40, 95 % CI 1.49 to 3.88) and multiple (aOR 4.91, 95 % CI 1.22 to 19.83) pregnancies.…”

Section: Resultsmentioning

confidence: 99%

“…Postpartum hemorrhage resulted increased in OD vs. IVF both in singleton (aOR 2.40, 95 % CI 1.49 to 3.88) and multiple (aOR 4.91, 95 % CI 1.22 to 19.83) pregnancies. No difference was detected in terms of GDM [155]. …”

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Risk of adverse pregnancy and perinatal outcomes after high technology infertility treatment: a comprehensive systematic review

Palomba

Homburg

Santagni

et al. 2016

Reprod Biol Endocrinol

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In the literature, there is growing evidence that subfertile patients who conceived after infertility treatments have an increased risk of pregnancy and perinatal complications and this is particularly true for patients who conceived through use of high technology infertility treatments. Moreover, high technology infertility treatments include many concomitant clinical and biological risk factors. This review aims to summarize in a systematic fashion the current evidence regarding the relative effect of the different procedures for high technology infertility treatments on the risk of adverse pregnancy and perinatal outcome. A literature search up to August 2016 was performed in IBSS, SocINDEX, Institute for Scientific Information, PubMed, Web of Science and Google Scholar and an evidence-based hierarchy was used to determine which articles to include and analyze. Data on prepregnancy maternal factors, low technology interventions, specific procedures for male factor, ovarian tissue/ovary and uterus transplantation, and chromosomal abnormalities and malformations of the offspring were excluded. The available evidences were analyzed assessing the level and the quality of evidence according to the Oxford Centre for Evidence-Based Medicine guidelines and the Grading of Recommendations Assessment, Development, and Evaluation system, respectively. Current review highlights that every single procedure of high technology infertility treatments can play a crucial role in increasing the risk of pregnancy and perinatal complications. Due to the suboptimal level and quality of the current evidence, further well-designed studies are needed.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Risk of adverse pregnancy and perinatal outcomes after high technology infertility treatment: a comprehensive systematic review

Palomba

Homburg

Santagni

et al. 2016

Reprod Biol Endocrinol

View full text Add to dashboard Cite

show abstract

“…In making this decision, the increased risks of pregnancy complications in connection with gestational surrogacy must be taken into account. A meta‐analysis showed that the risk of hypertension, preeclampsia and cesarean section was higher among women who had used oocyte donation, as in the case of gestational surrogacy, compared with IVF singleton pregnancies where the oocyte came from the women who carried the pregnancy .…”

Section: Discussionmentioning

confidence: 99%

Attitudes toward surrogacy among doctors working in reproductive medicine and obstetric care in Sweden

Stenfelt

Armuand

Wånggren

et al. 2018

Acta Obstet Gynecol Scand

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There is a relatively strong support among physicians working within obstetrics and reproductive medicine for the introduction of surrogacy in Sweden. However, the physicians expressed concerns about the surrogate mothers' health as well as the risk of coercion. Further discussions about legalization of surrogacy should include views from individuals within a wide field of different medical professions and laymen.

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Maternal and perinatal complications according to maternal age: A systematic review and meta‐analysis

Saccone

Ferrara

Marrone

et al. 2022

Intl J Gynecology & Obste

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Objective To evaluate the risk levels for maternal and perinatal complications at > 40, > 45 and > 50 years old compared with younger controls. Methods Electronic databases were searched from their inception until March 2021. We included studies reporting pregnancy outcome in pregnant women aged 40, 45, and 50 years or older compared with controls at the time of delivery. Case reports and case series were excluded. The primary outcome was the incidence of stillbirth. Meta‐analysis was performed using the random effects model of DerSimonian and Laird, to produce summary treatment effects in terms of relative risk (RR) with 95% confidence interval (CI). Heterogeneity was measured using I2 (Higgins I2). Subgroup analyses in women older than 45 years and in those older than 50 years were performed. Results Twenty‐seven studies, including 31 090 631 women, were included in the meta‐analysis. The overall quality of the included studies was moderate to high. Most of the included studies were retrospective cohort studies (21/27), four were population‐based studies, and two were cross‐sectional studies. Women aged ≥40 years had significantly higher risk of stillbirth (RR 2.16, 95% CI 1.86–2.51), perinatal mortality, intrauterine growth restriction, neonatal death, admission to neonatal intensive care unit, pre‐eclampsia, preterm delivery, cesarean delivery, and maternal mortality compared with women younger than 40 years old (RR 3.18, 95% CI 1.68–5.98). The increased risks for maternal mortality were 42.76 and 11.60 for women older than 50 years and for those older than 45 years, respectively, whereas those for stillbirth were 3.72 and 2.32. The risk of stillbirth and cesarean delivery was significantly higher in women >45 years compared with those aged 40–45 years, and in those aged >50 years compared with those aged 45–50 years. The risk of maternal mortality was significantly higher in women aged >50 years compared with those aged 40–45 (RR 60.40, 95% CI 13.28–274.74). Conclusion The risk of stillbirth, cesarean delivery, and maternal mortality increases with advancing maternal age. The risk ratios for maternal mortality were 3.18, 11.60, and 42.76 in women older than 40, older than 45, and older than 50 years, respectively. These data should be used when women with advanced maternal age are counseled regarding their risk in pregnancy. Systematic Review Registration The review was registered with the PROSPERO International Prospective Register of Systematic Reviews (registration No.: CRD42020208788).

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Obstetric and neonatal complications in pregnancies conceived after oocyte donation: a systematic review and meta‐analysis

Abstract: Oocyte donation pregnancies have increased risk of a range of obstetric and neonatal complications.

Cited by 140 publications

References 51 publications

Risk of adverse pregnancy and perinatal outcomes after high technology infertility treatment: a comprehensive systematic review

Risk of adverse pregnancy and perinatal outcomes after high technology infertility treatment: a comprehensive systematic review

Attitudes toward surrogacy among doctors working in reproductive medicine and obstetric care in Sweden

Maternal and perinatal complications according to maternal age: A systematic review and meta‐analysis

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