Obstetric and neonatal outcome in women with a history of recurrent miscarriage: a cohort study

Jivraj, Shehnaaz; Anstie, Barbara; Cheong, Ying; Fairlie, Fiona; Laird, SM; Li, T C

doi:10.1093/humrep/16.1.102

Cited by 117 publications

(93 citation statements)

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“…Hammoud et al (18) also noted a small increased risk (odds ratio of 1.13) of PTB and PPROM in women with a history of one miscarriage. Our findings are consistent with other studies showing adverse outcomes with increasing number of miscarriages (18)(19)(20). The association between SAB and subsequent PTB was also confirmed in a recent meta-analysis (10).…”

Section: Commentsupporting

confidence: 94%

513: Adverse pregnancy outcomes among women with prior spontaneous or induced abortions

Makhlouf

2011

American Journal of Obstetrics and Gynecology

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OBJECTIVE-To determine whether prior spontaneous (SAB) or induced (IAB) abortions, or the inter-pregnancy interval are associated with subsequent adverse pregnancy outcomes in nulliparous women.METHODS-We performed a secondary analysis of data collected from nulliparous women enrolled in a completed trial of vitamins C and E or placebo for preeclampsia prevention. Adjusted odds ratios for maternal and fetal outcomes were determined for nulliparous women with prior SABs and IABs as compared to primigravid participants. RESULTS-Comparedwith primigravidas, women with one prior SAB were at increased risk for perinatal death (OR 1.5; 95% CI 1.1-2.3) in subsequent pregnancies. Two or more SABs were associated with an increased risk for spontaneous preterm birth (OR 2.6, 95% CI 1.7-4.0), preterm PROM (OR 2.9, 95% CI 1.6-5.3) and perinatal death (OR 2.8, 95% CI 1.5-5.3). Women with one previous IAB had higher rates of spontaneous preterm birth (OR 1.4, 95% CI 1.0-1.9) and preterm PROM (OR 2.0, 95% CI 1.4-3.0). An inter-pregnancy interval less than 6 months after SAB was not associated with adverse outcomes.

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Section: Commentsupporting

confidence: 94%

513: Adverse pregnancy outcomes among women with prior spontaneous or induced abortions

Makhlouf

2011

American Journal of Obstetrics and Gynecology

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“…3 In our study, we found that the incidence of primary RPL was 75%, consistent with study by also reported higher rates of primary RPL. [4][5][6] We found only one study which reported secondary RPL to be more common. 7 Majority of 53% women showed identifiable causes.…”

Section: Discussionmentioning

confidence: 91%

An evaluation of recurrent pregnancy loss

Singh

Kujur

Rathore

2017

Int J Reprod Contracept Obstet Gynecol

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Background: This study was aimed to know the demographic profile and categorizes the causes of RPL.Methods: This observational study was carried out in the department of obstetrics and gynecology, Pt. J.N.M. Medical College Raipur from Nov 2015-Sept 2016. Total 100 women were evaluated with history of RPL.Results: 100 women were recruited in our study. The incidence of primary RPL was more than secondary RPL. 48 % women had first trimester abortions. The identifiable causes accounted for 53% out of which anatomical defects were the commonest .Next were endocrinal factors (20%), and Genetic factors (1%),Immunological factors 7%., Medical causes were 3%. However, 47% were unexplained.Conclusions: Despite innumerable investigations, sometimes or rather most of the times, the etiology remains obscure. It is this group of women who become a challenge to manage. Ultimately, most effective therapy for women with unexplained RPL is antenatal counseling, psychological support and tender loving care.

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“…Moreover, three or more successive losses affect 1%-2% of women of reproductive age, and two or more successive losses affect approximately 5% (12). Although several causes of recurrent pregnancy loss have been identified, 38% of cases remain unexplained (13,14). Thrombophilias have been suggested as a possible cause of recurrent miscarriage (RM) (15).…”

Section: Inherited Thrombophilia and Recurrent Pregnancy Lossmentioning

confidence: 99%

Inherited thrombophilia and reproductive disorders

Liatsikos

Tsikouras

Manav

et al. 2016

J Turkish German Gynecol Assoc

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Review 45 IntroductionThrombophilia is a disorder caused by inherited and acquired defects and is defined as a predisposition to thrombosis (1).The most common cause of acquired thrombophilia is the antiphospholipid syndrome (APS). Inherited thrombophilia constitutes a group of abnormalities of blood coagulation, including the factor V Leiden mutation (FVL) (homozygous or heterozygous), the prothrombin (FII) G20210A mutation (Pm) (homozygous or heterozygous), and deficiencies of the endogenous anticoagulants, antithrombin (AT), protein C, and protein S. Among these conditions, FVL and Pm are relatively common, while the others are rare. FVL is a point mutation (G1691A), resulting in an altered factor resistant to inactivation by protein C. The Pm leads to a 20%-50% increase in plasma prothrombin levels (2, 3). The prevalence of inherited thrombophilia in the general western population is estimated to be approximately 15% (4). However, it seems that there is a significant variation in the prevalence of these conditions among different geographical and tribal populations. FVL varies from 0.6% to 7.0%, with the lowest frequency observed in Africa (0%-0.6%) and the highest in Southern Europe (7%). The mean prevalence in Northern Europe is 4%. The prevalence of Pm varies from 0.2% to 3%, being lowest in Africa (0%-0.3%) and highest in Southern Europe (3%). The mean value in Northern Europe is 2%. Protein C, protein S, and AT deficiencies are extremely rare (0.2%-0.4%, 0.03%-0.1%, and 0.02%-0.2%, respectively) (5).The role of inherited thrombophilia in pregnancy loss and vascular gestational disorders has been investigated in several studies, and the results seem to be contradictory. The aim of this review was to elucidate the association of inherited thrombophilia and reproductive disorders. The value of screening women for inherited thrombophilia and the treatment options during pregnancy are also discussed.The association between inherited thrombophilia and reproductive disorders 1. Inherited thrombophilia and infertility Coulam et al. (6) reported that a prothrombotic tendency is associated with unexplained infertility, but this finding was not in agreement with data from Casadei et al. (7). To date, there has been no conclusive evidence in the literature to suggest an association of inherited thrombophilia and infertility other than recurrent implantation failure (8). Di Nisio et al. (9) conducted a systematic review and meta-analysis of all the available studies on the role of inherited thrombophilia in implantation failure. A significant association was found only for FVL [Odds ration (OR) 3.08; 95% confidence interval (CI) 1.77-5.36]. Inherited thrombophilia and recurrent pregnancy lossIt is estimated that approximately 25% of conceptions and 15% of all clinically recognized pregnancies end in a miscarriage (10, 11). Moreover, three or more successive losses affect 1%-2% of women of reproductive age, and two or more successive losses affect approximately 5% (12). Although several Apart from its established ro...

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Obstetric and neonatal outcome in women with a history of recurrent miscarriage: a cohort study

Cited by 117 publications

References 12 publications

513: Adverse pregnancy outcomes among women with prior spontaneous or induced abortions

513: Adverse pregnancy outcomes among women with prior spontaneous or induced abortions

An evaluation of recurrent pregnancy loss

Inherited thrombophilia and reproductive disorders

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